{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:47:27Z","timestamp":1766267247502},"reference-count":33,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2015,11,15]]},"abstract":"<jats:p> The role of stromal cell-derived factor-1\u03b1 (SDF-1\u03b1) expressed in infarcted myocardium is unknown in humans. We examined whether SDF-1\u03b1 produced in an infarcted myocardial lesion may play a role in left ventricle (LV) remodeling and dysfunction in patients with acute myocardial infarction (AMI). We measured SDF-1\u03b1 levels in plasma obtained from aortic root (AO) and anterior interventricular vein (AIV) in the early phase (2 wk after MI) and the chronic phase (6 mo after MI) in 80 patients with anterior MI. An increment in SDF-1\u03b1 level from AO to AIV, reflecting SDF-1\u03b1 release from infarcted myocardium, was more frequent in patients with MI in the early phase of MI [ n = 52 (65%), P = 0.03] but not in the chronic phase of MI [ n = 46 (58%), P = 0.11] compared with that in control patients [ n = 6\/17 (35%)]. On linear regression analysis, the transmyocardial gradient in SDF-1\u03b1 level in the chronic phase of MI was correlated with percentage changes in LV end-diastolic volume index ( r = 0.39, P &lt; 0.001), LV end-systolic volume index ( r = 0.38, P &lt; 0.001), and LV ejection fraction ( r = \u22120.26, P = 0.01) 6 mo after AMI. By contrast, the transmyocardial gradient of SDF-1\u03b1 in the early phase of MI had no significant correlations. In conclusion, the production of SDF-1\u03b1 in infarcted myocardium in the chronic phase of MI was associated with LV adverse remodeling and progressive dysfunction in AMI survivors. <\/jats:p>","DOI":"10.1152\/ajpheart.00493.2015","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T01:09:05Z","timestamp":1443229745000},"page":"H1764-H1771","source":"Crossref","is-referenced-by-count":20,"title":["Sustained myocardial production of stromal cell-derived factor-1\u03b1 was associated with left ventricular adverse remodeling in patients with myocardial infarction"],"prefix":"10.1152","volume":"309","author":[{"given":"Manabu","family":"Uematsu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Yoshizaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ei","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamitsu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Kugiyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147780.30124.CF"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14232-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:4:2:105"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-150"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/01.CIR.102.10.1193","volume":"102","author":"Braunwald E","year":"2000","journal-title":"Circulation"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nm1075"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12404"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090451"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-177287"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.02.001"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt153"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.031"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243162"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.09.011"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.672451"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914248107"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00185-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2008.01.047"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.033"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00850.2014"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148824.93600.F3"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.916346"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.06.031"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5403.845"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.4.1161"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0284-5"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.08.008"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90042-Y"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.694992"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.09.022"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.13-289"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.1.44"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.195"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00493.2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:29:36Z","timestamp":1567985376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00493.2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,15]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,11,15]]}},"alternative-id":["10.1152\/ajpheart.00493.2015"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00493.2015","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,15]]}}}