{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:37:38Z","timestamp":1762673858325},"reference-count":24,"publisher":"American Physiological Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p> Poorly synchronized activation of the ventricles can lead to impairment of normal cardiac structure\/function. We reported previously that short term (4 h) left ventricular (LV) pacing-induced ventricular dyskinesis led to an inflammatory response localized to the epicardium. Results from this study demonstrated that neutrophils may play a major role in this inflammatory process. Neutrophil recruitment to a site of injury is a process that is highly dependent on an upregulation of cell adhesion molecules (CAM). The dependence of ventricular dysynchrony-induced inflammatory responses on CAM upregulation has not been explored. To gain further insight, we used a mouse model of LV pacing to evaluate the role of CAM in mediating the inflammatory response associated with ventricular dyskinesis. We first examined the effects of LV pacing in wild-type mice. Results demonstrate that 40 min of LV pacing increases ICAM-1 immunostaining as well as myeloperoxidase activity and tissue oxidative stress by twofold in early-activated myocardium. Matrix metalloproteinase-9 activity also increased in the same region by \u223c3.5-fold. To determine the role of CAM, mice null for ICAM-1 or p-selectin were subjected to 40 min LV pacing. Results demonstrate that the inflammatory response seen in the wild-type mice was significantly mitigated in the ICAM-1 and p-selectin null mice. In conclusion, results demonstrate that CAM expression plays a critical role in the triggering of LV pacing-induced inflammation, thus providing evidence of a vascular mechanism underlying this response. The mechanisms that trigger an upregulation of myocardial CAM expression and, therefore, inflammation await further investigation since they suggest a specific involvement of vascular events. <\/jats:p>","DOI":"10.1152\/ajpheart.00496.2011","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T01:55:06Z","timestamp":1327110906000},"page":"H1387-H1393","source":"Crossref","is-referenced-by-count":9,"title":["Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing"],"prefix":"10.1152","volume":"302","author":[{"given":"Katrina Go","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, California State University Los Angeles, Los Angeles;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Hyun","family":"Ihm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Catholic University of Korea, Bucheon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego, La Jolla, California; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego, La Jolla, California; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Villarreal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego, La Jolla, California; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00281.2005"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00111-5"},{"key":"B3","first-page":"241","volume":"13","author":"Braddock M","year":"1998","journal-title":"News Physiol Sci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.1.H60"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.3.561"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0904554"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000143855.85343.0e"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.07.015"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00860.2004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00187-X"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1114\/1.1308487"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00160.2007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00403.2006"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1021\/bp970029f"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2007.02.003"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.10.7615157"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200004000-00010"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2000.4498"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.13.4879-4887.2000"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000038487.19924.18"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.06.015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2006.05.001"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8183.2003.01061.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01079.2010"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00496.2011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:25:28Z","timestamp":1567967128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00496.2011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,1]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,4,1]]}},"alternative-id":["10.1152\/ajpheart.00496.2011"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00496.2011","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,1]]}}}