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Glucose and lipid metabolism are both disordered in diabetes. Glucose and lipid metabolism disturbances promote myocardial fibrosis, apoptosis, and hypertrophy through galectin-3. Galectin-3 promotes cardiac remodeling by inhibiting phosphorylation of Akt\n                    <jats:sup>Thr308<\/jats:sup>\n                    or Akt\n                    <jats:sup>Ser473<\/jats:sup>\n                    . 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