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Matrix GLA protein (MGP) inhibits vascular calcification, and Mgp\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice develop severe MAC. Using this model, we found rapamycin (RAPA) prolonged lifespan, reduced arterial mineral density, maintained SMC contractile phenotype, and improved vessel structure, though calcification volume remained unchanged. 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