{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:13:51Z","timestamp":1793297631669,"version":"4.5.0"},"reference-count":49,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100000156","name":"Montreal Heart Institute Foundation","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"crossref","award":["283455"],"award-info":[{"award-number":["283455"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2017-04243"],"award-info":[{"award-number":["RGPIN-2017-04243"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["35775"],"award-info":[{"award-number":["35775"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-18-0022206"],"award-info":[{"award-number":["G-18-0022206"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p>It is generally accepted that older adults display an impaired cardiovascular response to heat stress, and it has been suggested that this impaired response contributes to their increased risk of mortality during extreme heat events. Seminal studies have shown that cutaneous vasodilation, the redistribution of blood flow from visceral organs, and the increase in cardiac output are blunted in older adults during passive heating. The blunted rise of cardiac output was initially attributed to an inability to maintain stroke volume, suggesting that cardiac systolic and\/or diastolic function does not adequately respond to the constraints of heat stress in older adults. Recent studies evaluated potential mechanisms underlying these seminal findings and their results challenge some of these initial observations. Notably, stroke volume is maintained during heat exposure in older adults and studies have provided evidence for preserved cardiac systolic and diastolic functions in this population. Nonetheless, a blunted increase in cardiac output during heat exposure remains a consistent observation in older adults, although it is now attributed to a blunted increase in heart rate. Recent studies have also evaluated the possibility that the attenuated capacity of aged skin to vasodilate contributes to a blunted increase in cardiac output during heat stress. The objective of this Mini-Review is to highlight these recent advances and challenge the long-standing view that the control of stroke volume during heat exposure is compromised in older adults. By doing so, our intent is to stimulate future studies to evaluate several unanswered questions in this area of research.<\/jats:p>","DOI":"10.1152\/ajpheart.00536.2020","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T14:01:59Z","timestamp":1607090519000},"page":"H411-H416","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Cardiovascular control during heat stress in older adults: time for an update"],"prefix":"10.1152","volume":"320","author":[{"given":"Hugo","family":"Gravel","sequence":"first","affiliation":[{"name":"Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia K.","family":"Chaseling","sequence":"additional","affiliation":[{"name":"Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadiatou","family":"Barry","sequence":"additional","affiliation":[{"name":"Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Debray","sequence":"additional","affiliation":[{"name":"Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-9489","authenticated-orcid":false,"given":"Daniel","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"School of Kinesiology and Exercise Science, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60935-1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098704"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxf007"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckl063"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1257469"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32594-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000325"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.4.1323"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140015"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1974.54.1.75"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.276.1.R203"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.28.4.415"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.6.864"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.143057"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.2.605"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1969.27.5.673"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00127.2011"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.170381"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01069.2008"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(70)90254-1"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(84)90069-9"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00498.2011"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(96)00134-8"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.15.5.505"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00643.2016"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1113\/JP274742"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1113\/JP270162"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00729.2015"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.083014"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.1.11"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/43.1.M1"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00338.2010"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.2741\/3642"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00871.2002"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108993"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.080952"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00730.2016"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00683.2001"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021265"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019217"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.3.805"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1042\/cs0870297"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90401.2008"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-007-0396-9"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.257.5.R1050"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001348"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2016.1230171"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1113\/EP085915"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1113\/EP087049"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00536.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T04:57:33Z","timestamp":1624424253000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00536.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,1]]}},"alternative-id":["10.1152\/ajpheart.00536.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00536.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"assertion":[{"value":"2020-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}