{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:47:13Z","timestamp":1779306433882,"version":"3.51.4"},"reference-count":27,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:p> Passive (papaverine induced) and active (spontaneous pressure induced) biomechanical properties of ischemic and nonischemic rat middle cerebral arteries (MCAs) were studied under pressurized conditions in vitro. Ischemic (1 h of occlusion), contralateral, and sham-operated control MCAs were isolated from male Wistar rats ( n = 22) and pressurized using an arteriograph system that allowed control of transmural pressure (TMP) and measurement of lumen diameter and wall thickness. Three mechanical stiffness parameters were computed: overall passive stiffness (\u03b2), pressure-dependent modulus changes ( E <jats:sub>inc,p<\/jats:sub>), and smooth muscle cell (SMC) activity-dependent changes ( E <jats:sub>inc,a<\/jats:sub>). The \u03b2-value for ischemic vessels was increased compared with sham vessels (13.9 \u00b1 1.7 vs. 9.1 \u00b1 1.4, P &lt; 0.05), indicating possible short-term remodeling due to ischemia. E <jats:sub>inc,p<\/jats:sub> increased with pressure in the passive vessels ( P &lt; 0.05) but remained relatively constant in the active vessels for all vessel types, indicating that pressure-induced SMC contractile activity (i.e., myogenic reactivity) in cerebral arteries leads to the maintenance of a constant elastic modulus within the autoregulatory pressure range. E <jats:sub>inc,a<\/jats:sub> increased with pressure for all conditions, signifying that changes in stiffness are influenced by SMC activity and vascular tone. <\/jats:p>","DOI":"10.1152\/ajpheart.00542.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:04:39Z","timestamp":1425413079000},"page":"H2268-H2275","source":"Crossref","is-referenced-by-count":30,"title":["Effects of ischemia and myogenic activity on active and  passive mechanical properties of rat cerebral arteries"],"prefix":"10.1152","volume":"283","author":[{"given":"Rebecca J.","family":"Coulson","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi C.","family":"Chesler","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Vitullo","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Vermont, Burlington, Vermont 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn J.","family":"Cipolla","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Vermont, Burlington, Vermont 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3263"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000020712.84444.8D"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1096\/cj.01-0104hyp"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.6.1223"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.4.940"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.7.1658"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.1.176"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1978.58.2.397"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1152\/ajplegacy.1969.217.6.1644","volume":"217","author":"Dobrin PB","year":"1969","journal-title":"Am J Physiol"},{"key":"B10","first-page":"S61","volume":"7","author":"Faraci FM","year":"1989","journal-title":"J Hypertens"},{"key":"B11","first-page":"415","volume":"28","author":"Goedhard WJ","year":"1973","journal-title":"Acta Cardiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02584246"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1984.246.1.H17"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(80)90191-8"},{"key":"B15","first-page":"211","volume":"17","author":"Hayashi K","year":"1980","journal-title":"Biorheology"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(87)90069-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109187"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(79)90015-0"},{"key":"B21","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1097\/00004872-198901000-00002","volume":"7","author":"Johansson B.","year":"1989","journal-title":"J Hypertens"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3995\/jstroke.8.1"},{"key":"B23","first-page":"S21","volume":"7","author":"Mellander S.","year":"1989","journal-title":"J Hypertens"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1982-19308"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.249.5.H914"},{"key":"B26","first-page":"S67","volume":"7","author":"Osol G","year":"1989","journal-title":"J Hypertens"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1042\/cs0960313"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.5.H2248"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1963.18.5.1041"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00542.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:16:40Z","timestamp":1567966600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00542.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,1]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12,1]]}},"alternative-id":["10.1152\/ajpheart.00542.2002"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00542.2002","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,1]]}}}