{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:58:41Z","timestamp":1740139121111,"version":"3.37.3"},"reference-count":32,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20POST35050017"],"award-info":[{"award-number":["20POST35050017"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL147976"],"award-info":[{"award-number":["R01 HL147976"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL133029"],"award-info":[{"award-number":["R01HL133029"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:p> We demonstrate that the modulation of p66Shc signaling impairs cerebral artery myogenic tone in a low renin model of hypertension. This impairment is dependent upon the genetic background, as modulated p66Shc signaling in Sprague-Dawley rats does not impair cerebral artery myogenic tone. <\/jats:p>","DOI":"10.1152\/ajpheart.00542.2021","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T17:32:42Z","timestamp":1635528762000},"page":"H1096-H1102","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension"],"prefix":"10.1152","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-9213","authenticated-orcid":true,"given":"William E.","family":"Hughes","sequence":"first","affiliation":[{"name":"Department of Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Hockenberry","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-4766","authenticated-orcid":true,"given":"Bradley","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-0190","authenticated-orcid":true,"given":"Andrey","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-7492","authenticated-orcid":true,"given":"Andreas M.","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/823525"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9562.S1-004"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00806"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13828"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt043"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-9-18"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000204043.18592.0d"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75079"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.06.025"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00414.2017"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.011"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119661"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0308"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800776RR"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.191551"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00012.2007"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs331"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02129"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8561892"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10865"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90636-i"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-10-0610"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000146279.11923.14"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00023"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.20.3.298"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.13.6.968"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00490.2012"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.02.008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.584135"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.11.009"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000189301.10217.87"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000338747"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00542.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T20:48:04Z","timestamp":1637182084000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00542.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12,1]]}},"alternative-id":["10.1152\/ajpheart.00542.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00542.2021","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"type":"print","value":"0363-6135"},{"type":"electronic","value":"1522-1539"}],"subject":[],"published":{"date-parts":[[2021,12,1]]},"assertion":[{"value":"2021-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}