{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:33:47Z","timestamp":1791110027443,"version":"4.1.0"},"reference-count":25,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p>Extracellular matrix (ECM) molecules such as elastin and collagen provide mechanical support to the vessel wall and are essential for vascular function. Evidence that genetic factors influence aortic ECM composition and organization was concluded from our previous studies showing that the inbred Brown Norway (BN) rat differs significantly from the outbred Long-Evans (LE) and the inbred LOU rat with respect to both thoracic aortic elastin content and internal elastic lamina (IEL) rupture in the abdominal aorta and iliac arteries. Here, we measured aortic elastin and collagen contents as well as factors that may modulate these parameters [insulin growth factor (IGF)-I, transforming growth factor (TGF)-\u03b2<jats:sub>1<\/jats:sub>, and matrix metalloproteinase (MMP)-2] in seven inbred rat strains, including BN and LOU. We also investigated whether IEL ruptures occur in strains other than BN. We showed that LOU, LE, BN, and Fischer 344 (F344) rats were significantly different for aortic elastin content and elastin-to-collagen ratio, whereas LE, Lewis, WAG, and Wistar-Furth (WF) were similar for these parameters. BN and F344 had the lowest values. BN was the only strain to present numerous IEL ruptures, whereas F344, LE, and WF presented a few and the other strains presented none. In addition, IGF-I and TGF-\u03b2<jats:sub>1<\/jats:sub>levels in the plasma and aorta differed significantly between strains, suggesting genetic control of their production. Because inbred rat strains provide interesting models for quantitative trait locus analysis, our results concerning elastin, collagen, IEL ruptures, and cytokines may provide a basis for the search for candidate genes involved in the control of these phenotypes.<\/jats:p>","DOI":"10.1152\/ajpheart.00544.2004","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:24:14Z","timestamp":1097195054000},"page":"H769-H777","source":"Crossref","is-referenced-by-count":33,"title":["Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains"],"prefix":"10.1152","volume":"288","author":[{"given":"Jacques","family":"Behmoaras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Osborne-Pellegrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Gauguier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Paule","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1002\/path.819"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.3.262"},{"key":"R3","unstructured":"Capdeville M, Coutard M, and Osborne-Pellegrin MJ.Spontaneous rupture of the internal elastic lamina in the rat: the manifestation of a genetically determined factor which may be linked to vascular fragility.Blood Vessels26: 197\u2013212, 1989."},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64447-1"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Foster JA, Rich CB, Miller M, Benedict MR, Richman RA, and Florini JR.Effect of age and IGF-I administration on elastin gene expression in rat aorta.J Gerontol A Biol Sci Med Sci45: B113\u2013B118, 1990.","DOI":"10.1093\/geronj\/45.4.B113"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.2001.6.3.183"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00065-9"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1159\/000025718"},{"key":"R9","unstructured":"Kahari VM, Olsen DR, Rhudy RW, Carrillo P, Chen YQ, and Uitto J.Transforming growth factor-beta up-regulates elastin gene expression in human skin fibroblasts. 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