{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:41:52Z","timestamp":1785426112799,"version":"3.56.0"},"reference-count":54,"publisher":"American Physiological Society","issue":"3","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2020T058"],"award-info":[{"award-number":["2020T058"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018890","name":"Dutch Cardiovascular Alliance","doi-asserted-by":"publisher","award":["2020B008RECONNEXT"],"award-info":[{"award-number":["2020B008RECONNEXT"]}],"id":[{"id":"10.13039\/100018890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["subaward to R01 HL173346"],"award-info":[{"award-number":["subaward to R01 HL173346"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>In contrast to acute responses, long-term treatment exerted little long-term afterload reduction and stroke volume augmentation in both HFpEF and HFrEF. Reverse remodeling was clearly present in HFrEF but was hardly observed in HFpEF. These results suggest a lesser importance of any increase in stroke volume (due afterload reduction) compared with reverse remodeling in the long-term effects of heart failure medication.<\/jats:p>","DOI":"10.1152\/ajpheart.00544.2024","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T08:00:56Z","timestamp":1737187256000},"page":"H419-H432","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-term hemodynamic responses and reverse remodeling after pharmacotherapy in HFpEF versus HFrEF: a systematic review and meta-analysis"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-7525","authenticated-orcid":false,"given":"Arno A.","family":"van de Bovenkamp","sequence":"first","affiliation":[{"name":"Vrije Universiteit Amsterdam","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Heart failure & Arrhythmias","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soufiane","family":"Nassiri","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Heart failure & Arrhythmias","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-9441","authenticated-orcid":false,"given":"Adrianus J.","family":"Bakermans","sequence":"additional","affiliation":[{"name":"University of Amsterdam","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-4179","authenticated-orcid":false,"given":"George L.","family":"Burchell","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-7793","authenticated-orcid":false,"given":"Frances S.","family":"de Man","sequence":"additional","affiliation":[{"name":"Amsterdam Cardiovascular Sciences, Heart failure & Arrhythmias","place":["The Netherlands"]},{"name":"Vrije Universiteit Amsterdam","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon B.","family":"van Loon","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Heart failure & Arrhythmias","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-7865","authenticated-orcid":false,"given":"M. Louis","family":"Handoko","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Heart failure & Arrhythmias","place":["The Netherlands"]},{"id":[{"id":"https:\/\/ror.org\/0575yy874","id-type":"ROR","asserted-by":"publisher"}],"name":"UMC Utrecht","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2016:25:2"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12005"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2022.23"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad195"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206286"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107038"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021165"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu204"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.310119"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft062"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.172"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6363-5"},{"key":"B14","volume-title":"StatPearls","author":"LaCombe P","year":"2023"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.062"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20160005"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-020-00287-7"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.05.010"},{"key":"B20","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins JPT","year":"2023"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(97)00344-6"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.12.004"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.54.3.305"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(85)80090-5"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.86.2.431"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.88.5.2277"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.117978"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.898916"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61227-6"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.12843"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.905"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.763"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14940"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011521"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173827"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01965-4"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052186"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.6827"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.14363"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.121269"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.015552"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.10.008"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.02.014"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.5320"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.08.073"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.03.017"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.06.004"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.shj.2022.100129"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198500301-00011"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.005"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.068788"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1436"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(97)00874-6"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1220"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00544.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T14:45:39Z","timestamp":1744382739000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00544.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,1]]}},"alternative-id":["10.1152\/ajpheart.00544.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00544.2024","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,1]]},"assertion":[{"value":"2024-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}