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Medetomidine and detomidine induce robust vasoconstriction that is abolished by the peripherally acting \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -adrenoceptor antagonist vatinoxan. These findings identify a distinct adrenergic hierarchy in chelonian vasculature, provide a mechanistic basis for the cardiovascular effects of \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -agonist sedation, and establish chelonians as a comparative model of \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -adrenoceptor-mediated vascular regulation.\n                  <\/jats:p>","DOI":"10.1152\/ajpheart.00563.2026","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:32:11Z","timestamp":1788877931000},"page":"H1242-H1251","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predominant \u03b1\n                    <sub>2<\/sub>\n                    -adrenoceptor control of chelonian systemic resistance arteries provides a mechanistic basis for the cardiovascular effects of \u03b1\n                    <sub>2<\/sub>\n               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