{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:28:50Z","timestamp":1791462530893,"version":"4.3.4"},"reference-count":50,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100000265","name":"UKRI | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K020366\/1"],"award-info":[{"award-number":["MR\/K020366\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UKRI | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K013157\/1"],"award-info":[{"award-number":["MR\/K013157\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/21\/10796"],"award-info":[{"award-number":["PG\/21\/10796"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/13\/47\/30337"],"award-info":[{"award-number":["PG\/13\/47\/30337"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["TG\/18\/3\/33773"],"award-info":[{"award-number":["TG\/18\/3\/33773"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"UKRI | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M008770\/1"],"award-info":[{"award-number":["BB\/M008770\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p>\n                    A novel potential treatment for peripheral arterial disease (PAD) is described. Inhibition of SRPK1, or knockout in monocytes, induces angiogenesis by preventing splicing to antiangiogenic VEGF (VEGF-A\n                    <jats:sub>165<\/jats:sub>\n                    b) in patients and animal models. In PAD, monocyte splicing control is different from other cell types and SRPK1 inhibition by drug-like compounds can alter macrophage phenotype and reverse PAD in mice. A\u00a0new cell-specific SRPK1-LoxP mouse is described.\n                  <\/jats:p>","DOI":"10.1152\/ajpheart.00564.2024","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T21:11:13Z","timestamp":1751317873000},"page":"H490-H504","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The splicing factor kinase SRPK1 is a therapeutic target for peripheral vascular disease"],"prefix":"10.1152","volume":"329","author":[{"given":"Sohni Ria","family":"Bhalla","sequence":"first","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mussarat","family":"Wahid","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason O.","family":"Amartey","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Zawia","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Riu","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1615-9617","authenticated-orcid":false,"given":"Yizhuo","family":"Gao","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9412-9186","authenticated-orcid":false,"given":"Jyoti","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-4809","authenticated-orcid":false,"given":"Maria J. C.","family":"Machado","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hawtrey","sequence":"additional","affiliation":[{"name":"University of New South Wales","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Gifu University Hospital","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn R.","family":"Green","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Teboul","sequence":"additional","affiliation":[{"name":"MRC Harwell Institute, Harwell Campus","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Allen","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Blackley","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthana","family":"Rajaji","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-4336","authenticated-orcid":false,"given":"Jennifer","family":"Batson","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Harper","sequence":"additional","affiliation":[{"name":"North Bristol NHS Trust, Southmead Hospital","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Oltean","sequence":"additional","affiliation":[{"name":"St Luke\u2019s Campus","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Amoaku","sequence":"additional","affiliation":[{"name":"University of Nottingham, Queen\u2019s Medical Centre","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew V.","family":"Benest","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-9069","authenticated-orcid":false,"given":"Jonathan C.","family":"Morris","sequence":"additional","affiliation":[{"name":"University of New South Wales","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Braithwaite","sequence":"additional","affiliation":[{"name":"Nottingham University Health Care Trust, Queen\u2019s Medical Centre","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-2360","authenticated-orcid":false,"given":"David O.","family":"Bates","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.99.17.2239"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2022.2104125"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.517219"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188280"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3703"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2011.03.002"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-1-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.817528"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2466"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.11.026"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2505"},{"key":"B12","first-page":"4123","volume":"62","author":"Bates DO","year":"2002","journal-title":"Cancer Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6577"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6254-9"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0934"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1159\/000177614"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4296"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.06.012"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309516"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034165"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/cells11172676"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2020.03.013"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10505-9"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b01048"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314298200"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.016410"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.10.016"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.074930"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.281"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00001.2022"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.360"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11634"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12422"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068399"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1181626"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07620-0"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.033"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2010.05.025"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.04.013"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.08.012"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.342"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2022.105385"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02161-x"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102423"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010041"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07992.x"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046539"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-021-01103-3"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.007"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008942828960"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00564.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T18:06:58Z","timestamp":1753726018000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00564.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8,1]]}},"alternative-id":["10.1152\/ajpheart.00564.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00564.2024","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.17.589996","asserted-by":"object"}]},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"assertion":[{"value":"2024-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}