{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:32:54Z","timestamp":1770269574948,"version":"3.49.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,2,1]]},"abstract":"<jats:p> Whereas the actual identity of endothelium-derived hyperpolarizing factor (EDHF) is still not certain, it involves a process requiring the endothelium and eliciting hyperpolarization and relaxation of smooth muscle. It is neither nitric oxide (NO) nor prostacyclin, and its presence has been demonstrated in a variety of vessels. Recent studies in peripheral vessels report that EDHF-mediated dilations were either attenuated or blocked by NO. Studies presented here demonstrate that NO does not block EDHF-mediated dilations in cerebral vessels. Rat middle cerebral arteries were cannulated, pressurized, and luminally perfused. EDHF-mediated dilations were elicited by the luminal application of ATP in the presence of N <jats:sup>G<\/jats:sup>-nitro-l-arginine methyl ester (l-NAME) and indomethacin (inhibitors of NO synthase and cyclooxygenase, respectively). These dilations persisted when S-nitroso- N-acetylpenicillamine, an NO donor, was added exogenously in the presence of l-NAME, or when endogenous NO was present but its cGMP actions were blocked by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, an inhibitor of guanylate cyclase. These findings demonstrate that the EDHF response is not suppressed by NO in cerebral vessels and suggests a role for EDHF during normal physiological conditions. <\/jats:p>","DOI":"10.1152\/ajpheart.00583.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:00:38Z","timestamp":1425394838000},"page":"H734-H738","source":"Crossref","is-referenced-by-count":26,"title":["Effect of NO on EDHF response  in rat middle cerebral arteries"],"prefix":"10.1152","volume":"282","author":[{"given":"Lisa A.","family":"Schildmeyer","sequence":"first","affiliation":[{"name":"Departments of Anesthesiology, Molecular Physiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Robert M.","family":"Bryan","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Molecular Physiology, and"},{"name":"Biophysics, and"},{"name":"Section of Cardiovascular Sciences, Department of Medicine Baylor College of Medicine, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3341"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.2.255"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.42"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199607000-00012"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.3.415"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.561bq.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.11.3337"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703474"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.3.H1272"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/24388"},{"key":"B11","first-page":"525","volume":"50","author":"Feletou M","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/46816"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)88969-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.6.H2417"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1089\/089771501750357636"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.4.H1759"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.1.H33"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)90633-7"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0844"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.2.H459"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15893.x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701032"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1159\/000025595"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.4.837"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03007.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701285"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.3.H893"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.3.H1472"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.5.1125"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15327.x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s002100000229"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00583.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:00:26Z","timestamp":1567954826000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00583.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,1]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2,1]]}},"alternative-id":["10.1152\/ajpheart.00583.2001"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00583.2001","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,1]]}}}