{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:13:59Z","timestamp":1787807639596,"version":"build-2784847793"},"reference-count":25,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL147968"],"award-info":[{"award-number":["R01HL147968"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL155344"],"award-info":[{"award-number":["R01HL155344"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL107594"],"award-info":[{"award-number":["HL107594"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD028597"],"award-info":[{"award-number":["S10OD028597"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX005065"],"award-info":[{"award-number":["I01BX005065"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX005981"],"award-info":[{"award-number":["I01BX005981"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wilkinson Foundation"},{"DOI":"10.13039\/501100000024","name":"Canadian Government | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Banting Postdoctoral Fellowships"],"award-info":[{"award-number":["Banting Postdoctoral Fellowships"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>This study shows that isoproterenol and lipopolysaccharide establish cardioprotection through the activation of distinct upstream signaling and cell-cell communication networks that converge on interferon signaling in the heart. Viewed together, these studies suggest an important role for immune-mediated cardioprotection as a mechanism for enhancing cardiac resilience in response to stress.<\/jats:p>","DOI":"10.1152\/ajpheart.00594.2025","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:21:27Z","timestamp":1760660487000},"page":"H1347-H1357","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative analysis of isoproterenol- and lipopolysaccharide-mediated cytoprotective responses in the heart"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-4183","authenticated-orcid":false,"given":"Kenji Rowel Q.","family":"Lim","sequence":"first","affiliation":[{"name":"Washington University in St. Louis","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6851-0168","authenticated-orcid":false,"given":"Junedh","family":"Amrute","sequence":"additional","affiliation":[{"name":"Washington University in St. Louis","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Diwan","sequence":"additional","affiliation":[{"name":"Washington University in St. Louis","place":["United States"]},{"name":"John Cochran Veterans Affairs Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2516-0145","authenticated-orcid":false,"given":"Douglas L.","family":"Mann","sequence":"additional","affiliation":[{"name":"Washington University in St. Louis","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","first-page":"1846","volume":"66","author":"Janke J","year":"1975","journal-title":"Minerva Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.74.5.1124"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000114828.98480.e0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.06.029"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142249"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.12.007"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226936"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaf158"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00684.2022"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15937"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.05.006"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv412"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00933"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaz1974"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.05.003"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1471"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-012-0238-z"},{"key":"B22","first-page":"239, 241","volume":"64","author":"Kitano H","year":"2007","journal-title":"Prog Drug Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011006200"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503120200"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98278"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00594.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:39:10Z","timestamp":1762868350000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00594.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1152\/ajpheart.00594.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00594.2025","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}