{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:09:09Z","timestamp":1760249349912,"version":"3.37.3"},"reference-count":39,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"Women an Child Health Research Institute"},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de recherche en sant\u00e9 du Canada)","doi-asserted-by":"publisher","award":["MOP299166"],"award-info":[{"award-number":["MOP299166"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:p> Doppler studies at rest suggest left ventricular (LV) diastolic function rapidly improves from the neonate to infant. Whether this translates to its response to hemodynamic challenges is uncertain. We sought to explore the impact of early LV maturation on its ability to tolerate atrial tachycardia. As tachycardia reduces filling time, we hypothesized that the neonatal LV would be less tolerant of atrial tachycardia. Landrace cross piglets of two age groups (1\u20133 days; NPs; 14\u201317 days, YPs; n = 7\/group) were instrumented for an atrial pacing protocol (from 200 to 300 beats\/min) and assessed by invasive monitoring and echocardiography. NPs maintained their LV output and blood pressure, whereas YPs did not. Although negative dP\/d t in NPs at baseline was lower than that of YPs (\u22121,599 \u00b1 83 vs. \u22122,470 \u00b1 226 mmHg\/s, respectively, P = 0.007), with increasing tachycardia negative dP\/d t converged between groups and was not different. Both groups had similar preload reduction during tachycardia; however, NPs maintained shortening fraction while YPs decreased (NPs: 35.4 \u00b1 1.4 vs. 31.8 \u00b1 2.2%, P = 0.35; YPs: 31.4 \u00b1 0.8 vs. 22.9 \u00b1 0.8%, P &lt; 0.001). Contractility measures did not differ between groups. Peak LV twist and untwisting rate also did not differ; however, NPs tended to augment LV twist through increased apical rotation and YPs through increasing basal rotation ( P = 0.009). The NPs appear more tolerant of atrial tachycardia than the YPs. They have at least similar diastolic performance, enhanced systolic performance, and different LV twist mechanics, which may contribute to improved tachycardia tolerance of NPs. <\/jats:p>","DOI":"10.1152\/ajpheart.00595.2015","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T22:23:12Z","timestamp":1451514192000},"page":"H598-H607","source":"Crossref","is-referenced-by-count":3,"title":["Postnatal neonatal myocardial adaptation is associated with loss of tolerance to tachycardia: a simultaneous invasive and noninvasive assessment"],"prefix":"10.1152","volume":"310","author":[{"given":"Etienne","family":"Fortin-Pellerin","sequence":"first","affiliation":[{"name":"Fetal and Neonatal Cardiology Program, Division of Cardiology, Women's and Children's Health Research Institute, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nee S.","family":"Khoo","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Cardiology Program, Division of Cardiology, Women's and Children's Health Research Institute, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Mills","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Cardiology Program, Division of Cardiology, Women's and Children's Health Research Institute, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Y.","family":"Coe","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Cardiology Program, Division of Cardiology, Women's and Children's Health Research Institute, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Serrano-Lomelin","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Women's and Children's Health Research Institute, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada; 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