{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:25:23Z","timestamp":1780514723534,"version":"3.54.1"},"reference-count":53,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100017540","name":"HHS | NIH | NHLBI | NHLBI Division of Intramural Research","doi-asserted-by":"publisher","award":["ZIA-HL-006210"],"award-info":[{"award-number":["ZIA-HL-006210"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"HHS | NIH | NHLBI | NHLBI Division of Intramural Research","doi-asserted-by":"publisher","award":["ZIA-HL-006212"],"award-info":[{"award-number":["ZIA-HL-006212"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:p> This work is the first to apply heart rate fragmentation analyses to individuals with Williams syndrome and posits that the heart rate fragmentation parameter W<jats:sub>3<\/jats:sub> may enable detection and investigation of phenomena underlying the proarrhythmic short-long-short RR interval sequences paradigm known to precede ventricular fibrillation and ventricular tachycardia. It also forwards a novel method for quantifying sinus arrhythmia and sinus pauses that likely correlate with parasympathetic activity. <\/jats:p>","DOI":"10.1152\/ajpheart.00601.2023","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T15:11:26Z","timestamp":1718982686000},"page":"H521-H532","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased heart rate fragmentation in those with Williams\u2013Beuren syndrome suggests nonautonomic mechanistic contributors to sudden death risk"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-6669","authenticated-orcid":false,"given":"Brianna M.","family":"Cathey","sequence":"first","affiliation":[{"name":"School of Engineering Medicine, Texas A&M University, Houston, Texas, United States"},{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3476-0097","authenticated-orcid":false,"given":"Anna","family":"Bellach","sequence":"additional","affiliation":[{"name":"Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Troendle","sequence":"additional","affiliation":[{"name":"Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Smith","sequence":"additional","affiliation":[{"name":"Nursing Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-9212","authenticated-orcid":false,"given":"Sharon","family":"Osgood","sequence":"additional","affiliation":[{"name":"Office of the Clinical Director, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Raja","sequence":"additional","affiliation":[{"name":"School of Engineering Medicine, Texas A&M University, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9757-7118","authenticated-orcid":false,"given":"Beth A.","family":"Kozel","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-9828","authenticated-orcid":false,"given":"Mark D.","family":"Levin","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.24.6.1311"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-11"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.7.1021"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(96)70042-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.02.016"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30012"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.10.010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90510-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(96)00279-3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000047275.25795.17"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1192188"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi188"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2005.04358.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2008.00211.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn537"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(97)11144-8"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1159\/000357200"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.610955"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.09.543"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197110142851602"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.064"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.1.47"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00255"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66709-z"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.049"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00827"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01117"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.7.913"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00026"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00399-008-0024-3"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/JP284391"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv015"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25573"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp013"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2014.6945157"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/app10093314"},{"key":"B40","first-page":"173","volume":"5","author":"Taylor EW","year":"1994","journal-title":"Cardioscience"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.40788.x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2007.11.005"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321668"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00578-6"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.984262"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055783"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51230-9"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.977827"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/anec.13034"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2011.10.006"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/s0972-6292(16)30461-2"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01037.2002"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00077-6"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.206078"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00615"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00601.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T17:13:06Z","timestamp":1723137186000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00601.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8,1]]}},"alternative-id":["10.1152\/ajpheart.00601.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00601.2023","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"assertion":[{"value":"2023-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}