{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:57:48Z","timestamp":1776463068862,"version":"3.51.2"},"reference-count":79,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p> Acute exhaustive exercise differentially impacts the right ventricle (RV) versus left ventricle (LV), yet the underlying hemodynamic basis remains unclear. Using pressure-volume analyses and pressure-telemetry implantation in mice, we confirmed a marked disproportionate and persistent negative impact of exhaustive exercise on the RV. These differences in responses of the ventricles to exhaustive exercise are of clinical relevance, reflecting \u223c2-fold greater hemodynamic RV loads versus LVs arising from massive (\u223c45 mmHg) increases in LV end-diastolic pressures at exhaustion. <\/jats:p>","DOI":"10.1152\/ajpheart.00603.2020","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T16:59:49Z","timestamp":1610125189000},"page":"H1261-H1275","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Differential negative effects of acute exhaustive swim exercise on the right ventricle are associated with disproportionate hemodynamic loading"],"prefix":"10.1152","volume":"320","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-0488","authenticated-orcid":false,"given":"Robert","family":"Lakin","sequence":"first","affiliation":[{"name":"Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Biology, York University, Toronto, Ontario, Canada"},{"name":"Division of Cardiology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-5955","authenticated-orcid":false,"given":"Ryan","family":"Debi","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, Ontario, Canada"},{"name":"Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazari","family":"Polidovitch","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, Ontario, Canada"},{"name":"Division of Cardiology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack M.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Cardiology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Backx","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, Ontario, Canada"},{"name":"Division of Cardiology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.7.963"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008141"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008142"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2015.06.005"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00898.2009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr397"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.110.961938"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/JP271889"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31821b12eb"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.101063"},{"key":"B11","first-page":"688","volume":"18","author":"Stewart GM","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.11.017"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl468"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00282-3"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.189621"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.959437"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-2090CI"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308592"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90176-P"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31820607a3"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000282"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.653576"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7018"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.12.045"},{"key":"B25","volume-title":"Resource Book for the Design of Animal Exercise Protocols","author":"Kregel KD","year":"2006"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.138"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00805.2010"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1109\/IEMBS.2006.259407"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.1.167"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.4.519"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.12.017"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.6.808"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00781.2011"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1986.250.6.R1021"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1301311"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318298a585"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2007.10.004"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.647461"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.04.022"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.12.002"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2016.1165292"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.05.018"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.08.003"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.05.004"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1177\/2047487315622298"},{"key":"B46","volume-title":"Cardiac Contraction and the Pressure-Volume Relationship","author":"Sagawa K","year":"1988"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0630-2"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.5.H1645"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00841"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173449"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00449.2011"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(85)80097-3"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv047"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00340.2011"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050488"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1042\/cs0870275"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(90)90078-D"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.674028"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.930701"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.0318"},{"key":"B61","first-page":"585","volume-title":"Handbook of Physiology, Exercise: Regulation and Integration of Multiple Systems","author":"Reeves JT","year":"1996"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.051540"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy138"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.2174\/157340308783565384"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)43030-4"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006345"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91342.2008"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130031"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2011.01376.x"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200006000-00005"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-091162"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.938282"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001471"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.041"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.03.017"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.1999.00535.x"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.3.765"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1873-1"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(14)61658-2"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00603.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T08:54:39Z","timestamp":1624438479000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00603.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"alternative-id":["10.1152\/ajpheart.00603.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00603.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"2020-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}