{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:40:28Z","timestamp":1790059228906,"version":"4.0.1"},"reference-count":59,"publisher":"American Physiological Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2013,6,15]]},"abstract":"<jats:p> Previous studies reported that diets high in simple carbohydrates could increase blood pressure in rodents. We hypothesized that the converse, a low-carbohydrate\/high-fat diet, might reduce blood pressure. Six-week-old spontaneously hypertensive rats (SHR; n = 54) and Wistar-Kyoto rats (WKY; n = 53, normotensive control) were fed either a control diet (C; 10% fat, 70% carbohydrate, 20% protein) or a low-carbohydrate\/high-fat diet (HF; 20% carbohydrate, 60% fat, 20% protein). After 10 wk, SHR-HF had lower ( P &lt; 0.05) mean arterial pressure than SHR-C (148 \u00b1 3 vs. 159 \u00b1 3 mmHg) but a similar degree of cardiac hypertrophy (33.4 \u00b1 0.4 vs. 33.1 \u00b1 0.4 heart weight\/tibia length, mg\/mm). Mesenteric arteries and the entire aorta were used to assess vascular function and endothelial nitric oxide synthase (eNOS) signaling, respectively. Endothelium-dependent (acetylcholine) relaxation of mesenteric arteries was improved ( P &lt; 0.05) in SHR-HF vs. SHR-C, whereas contraction (potassium chloride, phenylephrine) was reduced ( P &lt; 0.05). Phosphorylation of eNOS<jats:sup>Ser1177<\/jats:sup> increased ( P &lt; 0.05) in arteries from SHR-HF vs. SHR-C. Plasma glucose, insulin, and homoeostatic model of insulin assessment were lower ( P &lt; 0.05) in SHR-HF vs. SHR-C, whereas peripheral insulin sensitivity (insulin tolerance test) was similar. After a 10-h fast, insulin stimulation (2 U\/kg ip) increased ( P &lt; 0.05) phosphorylation of Akt<jats:sup>Ser473<\/jats:sup> and S6 in heart and gastrocnemius similarly in SHR-C vs. SHR-HF. In conclusion, a low-carbohydrate\/high-fat diet reduced blood pressure and improved arterial function in SHR without producing signs of insulin resistance or altering insulin-mediated signaling in the heart, skeletal muscle, or vasculature. <\/jats:p>","DOI":"10.1152\/ajpheart.00631.2012","type":"journal-article","created":{"date-parts":[[2013,4,20]],"date-time":"2013-04-20T03:35:16Z","timestamp":1366428916000},"page":"H1733-H1742","source":"Crossref","is-referenced-by-count":20,"title":["A low-carbohydrate\/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance"],"prefix":"10.1152","volume":"304","author":[{"given":"John D.","family":"Bosse","sequence":"first","affiliation":[{"name":"Division of Nutrition, University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Nutrition, University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Sloan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Jiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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