{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:33:04Z","timestamp":1767771184338,"version":"3.37.3"},"reference-count":49,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL070653","HL129797"],"award-info":[{"award-number":["HL070653","HL129797"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL144528"],"award-info":[{"award-number":["HL144528"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p>As the highest fructose consumers, the adolescent population is highly susceptible to the metabolic syndrome, where increases in mast cell chymase-dependent formation of ANG II, ensued by cardiometabolic dysfunction, are reversible in response to inhibition of soluble epoxide hydrolase (sEH). This study highlights chymase and sEH as therapeutic targets and unravels novel avenues for the development of optimal strategies for young patients with fructose-induced metabolic syndrome.<\/jats:p>","DOI":"10.1152\/ajpheart.00633.2019","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T19:10:41Z","timestamp":1584126641000},"page":"H985-H993","source":"Crossref","is-referenced-by-count":15,"title":["The contribution of chymase-dependent formation of ANG II to cardiac dysfunction in metabolic syndrome of young rats: roles of fructose and EETs"],"prefix":"10.1152","volume":"318","author":[{"given":"Ghezal","family":"Froogh","sequence":"first","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-0325","authenticated-orcid":false,"given":"Sharath","family":"Kandhi","sequence":"additional","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roopa","family":"Duvvi","sequence":"additional","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicong","family":"Le","sequence":"additional","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zan","family":"Weng","sequence":"additional","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan O.","family":"Ashe","sequence":"additional","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Sun","sequence":"additional","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Huang","sequence":"additional","affiliation":[{"name":"Departments of Physiology, New York Medical College, Valhalla, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25741"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.07.100"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703229104"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1076\/apab.111.1.17.15140"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/iub.241"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1134\/S000629791612018X"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature00786"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.10.022"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00219.2016"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.059"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00534.2016"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.6.1141"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1089\/152308602762197443"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature25013"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.2.526"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01222"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.268"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.6.1399"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2875"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2012.012225"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/hy0202.103788"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.02.028"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1039\/C4PP00304G"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.41"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00641.2009"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000707"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.06.001"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/02772240903306409"},{"key":"B29","doi-asserted-by":"crossref","first-page":"133.5","DOI":"10.4049\/jimmunol.182.Supp.133.5","volume":"182","author":"Min D","year":"2009","journal-title":"J Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0179-7"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2010.10.003"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.202424"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00519.2009"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.268029"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1285-z"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307708"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2001"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.100461"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00767.2016"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00920.2013"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1159\/000087569"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-009-0184-4"},{"key":"B43","first-page":"160","volume":"10","author":"Vos MB","year":"2008","journal-title":"Medscape J Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1241"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01433"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00080.2018"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.11.992"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040335"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5234"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00633.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T16:46:00Z","timestamp":1695919560000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00633.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,1]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4,1]]}},"alternative-id":["10.1152\/ajpheart.00633.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00633.2019","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"type":"print","value":"0363-6135"},{"type":"electronic","value":"1522-1539"}],"subject":[],"published":{"date-parts":[[2020,4,1]]}}}