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Carvedilol inhibits sodium and calcium currents and leads to failure of ECC but also prevents spontaneous Ca<jats:sup>2+<\/jats:sup> release from cellular sarcoplasmic reticulum (SR) Ca<jats:sup>2+<\/jats:sup> stores in form of arrhythmogenic Ca<jats:sup>2+<\/jats:sup> waves. 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