{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:58:31Z","timestamp":1740139111515,"version":"3.37.3"},"reference-count":12,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"NIH","award":["HL32788","R0183366"],"award-info":[{"award-number":["HL32788","R0183366"]}]},{"DOI":"10.13039\/100002584","name":"American Historical Association (AHA)","doi-asserted-by":"publisher","award":["09POST2290021"],"award-info":[{"award-number":["09POST2290021"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Malaysia","award":["FRGS\/1\/2015\/SKK08\/UNIM\/03\/2"],"award-info":[{"award-number":["FRGS\/1\/2015\/SKK08\/UNIM\/03\/2"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation (BHF)","doi-asserted-by":"publisher","award":["RG\/08\/009\/25841"],"award-info":[{"award-number":["RG\/08\/009\/25841"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:p> Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of the normal vessel wall has not been described. We examined JCR:LA control (+\/+) or cp\/cp rats fed normal chow diet for 6 or 18 mo. JCR:LA-cp rats developed multiple features of advanced cystic medial necrosis including \u201ccysts,\u201d increased collagen formation and proteoglycan deposition around cysts, apoptosis of vascular smooth muscle cells, and spotty medial calcification. These appearances began within 6 mo and were extensive by 18 mo. JCR:LA-cp rats had reduced medial cellularity, increased medial thickness, and vessel hypoxia that was most marked in the adventitia. In conclusion, the normal chow-fed JCR:LA-cp rat represents a novel rodent model of cystic medial necrosis, associated with multiple metabolic abnormalities, vascular smooth muscle cell apoptosis, and vessel hypoxia. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Triggers for cystic medial necrosis (CMN) have been difficult to study due to lack of animal models to recapitulate the pathologies seen in humans. Our study is the first description of CMN in the rat. Thus the JCR:LA-cp rat represents a useful model to investigate the underlying molecular changes leading to the development of CMN. <\/jats:p>","DOI":"10.1152\/ajpheart.00653.2016","type":"journal-article","created":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T20:56:36Z","timestamp":1481921796000},"page":"H541-H545","source":"Crossref","is-referenced-by-count":2,"title":["The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis"],"prefix":"10.1152","volume":"312","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-3970","authenticated-orcid":false,"given":"Yuh Fen","family":"Pung","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, University of Nottingham (Malaysia Campus), Semenyih, Selangor, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Chilian","sequence":"additional","affiliation":[{"name":"Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichola","family":"Figg","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Hamzah","family":"Kamarulzaman","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Serdang Hospital, Kajang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90482-8"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.175976"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(90)90062-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(87)90200-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.11.004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985816"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00012-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.7.6.620"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006828724405"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.9.6.869"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600012103"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1266\/ggs.81.41"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00653.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:47:05Z","timestamp":1567993625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00653.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3,1]]}},"alternative-id":["10.1152\/ajpheart.00653.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00653.2016","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"type":"print","value":"0363-6135"},{"type":"electronic","value":"1522-1539"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}