{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:11:07Z","timestamp":1792678267084,"version":"4.5.0"},"reference-count":48,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p> BIBF1000 is a small molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), and platelet-derived growth factor receptor (PDGFR) and is a powerful inhibitor of fibrogenesis. BIBF1000 is very similar to BIBF1120 (nintedanib), a drug recently approved for the treatment of idiopathic pulmonary fibrosis (IPF). A safety concern pertaining to VEGFR, FGFR, and PDGFR inhibition is the possible interference with right ventricular (RV) responses to an increased afterload, which could adversely affect clinical outcome in patients with IPF who developed pulmonary hypertension. We tested the effect of BIBF1000 on the adaptation of the RV in rats subjected to mechanical pressure overload. BIBF1000 was administered for 35 days in pulmonary artery-banded (PAB) rats. RV adaptation was assessed by echocardiography, pressure volume loop analysis, histology, and determination of atrial natriuretic peptide (ANP) expression. BIBF1000 treatment resulted in growth attenuation but had no effects on RV function after PAB, given absence of changes in cardiac index, end-systolic elastance, connective tissue disposition, and capillary density. We conclude that, in this experimental model of increased afterload, combined VEGFR, FGFR, and PDGFR inhibition does not hamper RV adaptation to pressure overload. <\/jats:p>","DOI":"10.1152\/ajpheart.00656.2015","type":"journal-article","created":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T06:05:21Z","timestamp":1466921121000},"page":"H604-H612","source":"Crossref","is-referenced-by-count":18,"title":["Tyrosine kinase inhibitor BIBF1000 does not hamper right ventricular pressure adaptation in rats"],"prefix":"10.1152","volume":"311","author":[{"given":"Michiel Alexander","family":"de Raaf","sequence":"first","affiliation":[{"name":"Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands;"},{"name":"INSERM UMR-S 999, H\u00f4pital Marie Lannelongue, Le Plessis-Robinson, France;"},{"name":"Universit\u00e9 Paris-Sud and Universit\u00e9 Paris-Saclay, School of Medicine, Kremlin-Bic\u00eatre, France;"},{"name":"Department of Physiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska Elena","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma, Dept. 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