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These encouraging findings in rodents led to initiation of a clinical trial using a H\n                    <jats:sub>2<\/jats:sub>\n                    S donor in heart failure patients. However, the underlying molecular mechanisms by which H\n                    <jats:sub>2<\/jats:sub>\n                    S mitigates cardiac remodeling are not completely understood. Empirical evidence suggest that H\n                    <jats:sub>2<\/jats:sub>\n                    S may regulate signaling pathways either by directly influencing a gene in the cascade or interacting with nitric oxide (another cardioprotective gasotransmitter) or both. Recent studies revealed that H\n                    <jats:sub>2<\/jats:sub>\n                    S may ameliorate cardiac dysfunction by up- or downregulating specific microRNAs. MicroRNAs are noncoding, conserved, regulatory RNAs that modulate gene expression mostly by translational inhibition and are emerging as a therapeutic target for cardiovascular disease (CVD). Few microRNAs also regulate H\n                    <jats:sub>2<\/jats:sub>\n                    S biosynthesis. The inter-regulation of microRNAs and H\n                    <jats:sub>2<\/jats:sub>\n                    S opens a new avenue for exploring the H\n                    <jats:sub>2<\/jats:sub>\n                    S-microRNA crosstalk in CVD. This review embodies regulatory mechanisms that maintain the physiological level of H\n                    <jats:sub>2<\/jats:sub>\n                    S, exogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S donors used for increasing the tissue levels of H\n                    <jats:sub>2<\/jats:sub>\n                    S, H\n                    <jats:sub>2<\/jats:sub>\n                    S-mediated regulation of CVD, H\n                    <jats:sub>2<\/jats:sub>\n                    S-microRNAs crosstalk in relation to the pathophysiology of heart disease, clinical trials on H\n                    <jats:sub>2<\/jats:sub>\n                    S, and future perspectives for H\n                    <jats:sub>2<\/jats:sub>\n                    S as a therapeutic agent for heart failure.\n                  <\/jats:p>","DOI":"10.1152\/ajpheart.00660.2015","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T20:41:55Z","timestamp":1453495315000},"page":"H802-H812","source":"Crossref","is-referenced-by-count":41,"title":["Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases"],"prefix":"10.1152","volume":"310","author":[{"given":"Bryan T.","family":"Hackfort","sequence":"first","affiliation":[{"name":"Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paras K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska; and"},{"name":"Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.157106"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.643365"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.03.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161023651"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2014.11.016"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.12.013"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(80)90346-9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00598.2010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2015.01.005"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705710104"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18144-8_8"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.2.162"},{"key":"B17","first-page":"62","volume":"26","author":"Bruere MA","year":"1891","journal-title":"J Anat Physiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.255216"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1021\/jm901638j"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2882"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199919"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1177\/1074248414552902"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nm1582"},{"key":"B25","unstructured":"Centers for Disease Control and Prevention. 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