{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:49:53Z","timestamp":1761580193367},"reference-count":44,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p> Our objective was to create an animal preparation displaying long-term electrical alterations after chronic regional energetic stress without myocardial scarring. An Ameroid (AM) constrictor was implanted around the left circumflex coronary artery (LCx) 2 wk before chronic rapid ventricular pacing (CRP) was initiated at 240 beats\/min for 4 wk (CRP-AM). Comparisons were made with healthy canines and canines with either AM or CRP. Unipolar electrograms were recorded from 191 sites in the LCx territory in open-chest, anesthetized animals during sinus rhythm and while pacing at 120\u2013150 beats\/min, with bouts of transient rapid pacing (TRP; 240\/min). In CRP-AM and AM, ST segment elevation was identified at central sites and ST depression at peripheral sites, both increasing with TRP. In CRP-AM and CRP, the maximum negative slope of unipolar activation complexes was significantly depressed and activation-recovery intervals prolonged. Areas of inexcitability as well as irregular isocontour patterns displaying localized activation-recovery intervals shortening and gradients &gt;20 ms between neighboring sites were identified in one-third of CRP-AM at slow rate, with increasing incidence and magnitude in response to TRP. In CRP-AM, programmed stimulation-induced marked conduction delay and block as well as polymorphic ventricular tachycardias, which stabilized into monomorphic tachycardias with the use of lidocaine or procainamide. Whole cell Na<jats:sup>+<\/jats:sup> current and channel protein expression were reduced in CRP-AM and CRP. Despite complete constrictor closure, small areas of necrosis were detected in a minority of CRP-AM. Long-term electrical alterations and their exacerbation by TRP contribute to arrhythmia formation in collateral-dependent myocardium subjected to chronic tachycardic stress. <\/jats:p>","DOI":"10.1152\/ajpheart.00679.2003","type":"journal-article","created":{"date-parts":[[2004,3,12]],"date-time":"2004-03-12T13:52:56Z","timestamp":1079099576000},"page":"H1496-H1506","source":"Crossref","is-referenced-by-count":8,"title":["Myocardial electrical alteration in canine preparations with combined chronic rapid pacing and progressive coronary artery occlusion"],"prefix":"10.1152","volume":"286","author":[{"given":"Ren\u00e9","family":"Cardinal","sequence":"first","affiliation":[{"name":"Departments of Pharmacology, Pathology and Cell Biology, and Surgery, Universit\u00e9 de Montr\u00e9al, and Research Center, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada H4J 1C5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology, Pathology and Cell Biology, and Surgery, Universit\u00e9 de Montr\u00e9al, and Research Center, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada H4J 1C5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology, Pathology and Cell Biology, and Surgery, Universit\u00e9 de Montr\u00e9al, and Research Center, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada H4J 1C5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology, Pathology and Cell Biology, and Surgery, Universit\u00e9 de Montr\u00e9al, and Research Center, 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