{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:35:10Z","timestamp":1789623310567,"version":"build-2803163510"},"reference-count":36,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["AN 4345132"],"award-info":[{"award-number":["AN 4345132"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wilkinson Foundation"},{"DOI":"10.13039\/100007716","name":"MSD Life Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012630","name":"Life Science Foundation of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000023","name":"Government of Canada | Banting Postdoctoral Fellowships","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["Universal Process APQ-01039-21"],"award-info":[{"award-number":["Universal Process APQ-01039-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL147968"],"award-info":[{"award-number":["R01HL147968"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL155344"],"award-info":[{"award-number":["R01 HL155344"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"HHS | NIH | NIH Office of the Director","doi-asserted-by":"publisher","award":["S10 OD028597"],"award-info":[{"award-number":["S10 OD028597"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:p>The present study highlights the importance of sexual dimorphism with respect to isoproterenol injury, as well as the importance of animal handling and welfare to obtain reproducible results from investigator to investigator. Based on serial observations of animal recovery (locomotor activity and grooming behavior), troponin I release, and inflammation, we identified that the method used to restrain the mice for the intraperitoneal injection was the single greatest source of variability in this model.<\/jats:p>","DOI":"10.1152\/ajpheart.00684.2022","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T11:38:11Z","timestamp":1671795491000},"page":"H229-H240","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Refining the reproducibility of a murine model of stress-induced reversible cardiomyopathy"],"prefix":"10.1152","volume":"324","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-7629","authenticated-orcid":false,"given":"Tomohiro","family":"Hayashi","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajal K.","family":"Tiwary","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-4183","authenticated-orcid":false,"given":"Kenji Rowel Q.","family":"Lim","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-0654","authenticated-orcid":false,"given":"Cibele","family":"Rocha-Resende","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-7512","authenticated-orcid":false,"given":"Carla","family":"Weinheimer","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2516-0145","authenticated-orcid":false,"given":"Douglas L.","family":"Mann","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.05.006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.10.002"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb16735.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607391200"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2828(85)80130-9"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.2.790"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.156236"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.044581"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15937"},{"key":"B10","first-page":"1","author":"Bollen K","year":"2015","journal-title":"National Science Foundation"},{"key":"B11","volume-title":"Neglected Factors in Pharmacology and Neuroscience Research: Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions","author":"Claassen V","year":"1994"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12318"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004351"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00890.2014"},{"key":"B15","first-page":"443","volume":"67","author":"Rona G","year":"1959","journal-title":"AMA Arch Pathol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199412000-00009"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.128961"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs161"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308687"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232507"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00212-5"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000921"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00734.2013"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2018.08.006"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.01.064"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2018.2.03"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933940"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32834a6697"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2020.06.002"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309357948"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-008-9022-2"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00711.2010"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0103"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2002.282.1.H256"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1159\/000502112"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.111591"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00684.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T12:30:00Z","timestamp":1674477000000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00684.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,1]]}},"alternative-id":["10.1152\/ajpheart.00684.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00684.2022","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]},"assertion":[{"value":"2022-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}