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Recent evidence demonstrates that exposure to heat stress can improve vascular function and reduce the risk of CVD in uninjured populations. We therefore aimed to examine the extent of vascular dysfunction in SCI and the acute effects of passive heating. Fifteen participants with cervical SCI and 15 uninjured control (CON) participants underwent ultrasound assessments of vascular function and venous blood sampling for biomarkers of endothelial activation (i.e., CD62e<jats:sup>+<\/jats:sup>) and apoptosis (i.e., CD31<jats:sup>+<\/jats:sup>\/42b<jats:sup>\u2212<\/jats:sup>) before and after a 60-min exposure to lower limb hot water immersion (40\u00b0C). In SCI, macrovascular endothelial function was reduced in the brachial artery [SCI: 4.8 (3.2)% vs. CON: 7.6 (3.4)%, P = 0.04] but not the femoral artery [SCI: 3.7 (2.6)% vs. CON: 4.0 (2.1)%, P = 0.70]. Microvascular function, via reactive hyperemia, was ~40% lower in SCI versus CON in both the femoral and brachial arteries ( P &lt; 0.01). Circulating concentrations of CD62e<jats:sup>+<\/jats:sup> were elevated in SCI versus CON [SCI: 152 (106) microparticles\/\u00b5l vs. CON: 58 (24) microparticles\/\u00b5l, P &lt; 0.05]. In response to heating, macrovascular and microvascular function remained unchanged, whereas increases (+83%) and decreases (\u221293%) in antegrade and retrograde shear rates, respectively, were associated with heat-induced reductions of CD62e<jats:sup>+<\/jats:sup> concentrations in SCI to levels similar to CON ( P = 0.05). These data highlight the potential of acute heating to provide a safe and practical strategy to improve vascular function in SCI. The chronic effects of controlled heating warrant long-term testing. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Individuals with cervical level spinal cord injury exhibit selectively lower flow-mediated dilation in the brachial but not femoral artery, whereas peak reactive hyperemia was lower in both arteries compared with uninjured controls. After 60 min of lower limb hot water immersion, femoral artery blood flow and shear patterns were acutely improved in both groups. Elevated biomarkers of endothelial activation in the spinal cord injury group decreased with heating, but these biomarkers remained unchanged in controls. <\/jats:p>","DOI":"10.1152\/ajpheart.00693.2018","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T09:43:04Z","timestamp":1545385384000},"page":"H722-H733","source":"Crossref","is-referenced-by-count":30,"title":["Acute heat stress reduces biomarkers of endothelial activation but not macro- or microvascular dysfunction in cervical spinal cord injury"],"prefix":"10.1152","volume":"316","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-0013","authenticated-orcid":false,"given":"Geoff B.","family":"Coombs","sequence":"first","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health, University of British Columbia Okanagan, Kelowna, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto F.","family":"Barak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron A.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Pharmacology, Cardiac Sciences, Clinical Neurosciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Mijacika","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology, School of Medicine, University of Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe K.","family":"Sarafis","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda H. 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