{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:32Z","timestamp":1787017772020,"version":"build-2736575974"},"reference-count":42,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p>\n                    The arterial baroreflex has dominant control over multiunit muscle sympathetic nerve activity (MSNA) burst occurrence, but whether this extends to all single units or is influenced by resting blood pressure status is unclear. In 22 men (32\u2009\u00b1\u20098 yr), we assessed 68 MSNA single units during sequential bolus injections of nitroprusside and phenylephrine (modified Oxford). Sympathetic baroreflex sensitivity (sBRS) was quantified as the weighted negative linear regression slope between diastolic blood pressure (DBP) and single-unit spike firing probability and multiple spike firing. Strong negative linear relationships ( r \u2265 \u22120.50) between DBP and spike firing probability were observed in 63\/68 (93%) single units (\u22122.27\u2009\u00b1 1.27%\u00b7cardiac cycle\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    [operating range, 18\u2009\u00b1\u20098 mmHg]). In contrast, only 45\/68 (66%) single units had strong DBP-multiple spike firing relationships (\u22120.13\u2009\u00b1\u20090.18 spikes\u00b7cardiac cycle\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    [operating range, 14\u2009\u00b1\u20097 mmHg]). Participants with higher resting DBP (65\u2009\u00b1\u20093 vs. 77\u2009\u00b1\u20093 mmHg, P &lt; 0.001) had similar spike firing probability sBRS (low vs. high, \u22122.08\u2009\u00b1\u20091.08 vs. \u22122.46\u2009\u00b1 1.42%\u00b7cardiac cycle\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , P = 0.33), but a smaller sBRS operating range (20\u2009\u00b1\u20096 vs. 16\u2009\u00b1\u20099 mmHg, P = 0.01; 86\u2009\u00b1\u200924 vs. 52\u2009\u00b1\u200925% of total range, P &lt; 0.001) and a higher proportion of single units without arterial baroreflex control outside this range [6\/31 (19%) vs. 21\/32 (66%), P &lt; 0.001]. Participants with higher resting DBP also had fewer single units with arterial baroreflex control of multiple spike firing (79 vs. 53%, P = 0.04). The majority of MSNA single units demonstrate strong arterial baroreflex control over spike firing probability during pharmacological manipulation of blood pressure. Changes in single-unit sBRS operating range and control of multiple spike firing may represent altered sympathetic recruitment patterns associated with the early development of hypertension.\n                  <\/jats:p>\n                  <jats:p>NEW &amp; NOTEWORTHY Muscle sympathetic single units can be differentially controlled during stress. In contrast, we demonstrate that 93% of single units maintain strong arterial baroreflex control during pharmacological manipulation of blood pressure. Interestingly, the operating range and proportion of single units that lose arterial baroreflex control outside of this range are influenced by resting blood pressure levels. Altered single unit, but not multiunit, arterial baroreflex control may represent changes in sympathetic recruitment patterns in early stage development of hypertension.<\/jats:p>","DOI":"10.1152\/ajpheart.00700.2019","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T13:06:12Z","timestamp":1583499972000},"page":"H937-H946","source":"Crossref","is-referenced-by-count":16,"title":["Arterial baroreflex regulation of muscle sympathetic single-unit activity in men: influence of resting blood pressure"],"prefix":"10.1152","volume":"318","author":[{"given":"Anthony V.","family":"Incognito","sequence":"first","affiliation":[{"name":"Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada"},{"name":"NeuroV\u0307ASQ\u0307-Integrative Physiology Laboratory, Faculty of Physical Education, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6348-1786","authenticated-orcid":false,"given":"Milena","family":"Samora","sequence":"additional","affiliation":[{"name":"NeuroV\u0307ASQ\u0307-Integrative Physiology Laboratory, Faculty of Physical Education, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta A.","family":"Cartafina","sequence":"additional","affiliation":[{"name":"NeuroV\u0307ASQ\u0307-Integrative Physiology Laboratory, Faculty of Physical Education, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel M. N.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"University Hospital, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Daher","sequence":"additional","affiliation":[{"name":"NeuroV\u0307ASQ\u0307-Integrative Physiology Laboratory, Faculty of Physical Education, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2177-1061","authenticated-orcid":false,"given":"Philip J.","family":"Millar","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-0295","authenticated-orcid":false,"given":"Lauro C.","family":"Vianna","sequence":"additional","affiliation":[{"name":"NeuroV\u0307ASQ\u0307-Integrative Physiology 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