{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:51Z","timestamp":1787017671171,"version":"build-2736575974"},"reference-count":36,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"\n In patients with high thoracic spinal lesions that remove most of the central drive to splanchnic preganglionic neurons, visceral or nociceptive stimuli below the lesion can provoke large increases in blood pressure (autonomic dysreflexia). We have examined the effects of T\n 4<\/jats:sub>\n spinal transection on isometric contractions of mesenteric arteries isolated from spinalized rats. Nerve-evoked contractions involved synergistic roles for norepinephrine and ATP. At 7 wk after spinal transection, responses to perivascular stimulation at 1\u20135 Hz were enhanced fivefold, whereas the \u03b1\n 1<\/jats:sub>\n -adrenoceptor antagonist prazosin (10 nM) produced a twofold larger reduction in contraction (to 20 pulses at 10 Hz) than in unoperated controls. In contrast, the reduction in nerve-evoked contractions by the P2-purinoceptor antagonist suramin (0.1 mM) and the responses to the P2-purinoceptor agonist \u03b1,\u03b2-methylene ATP or to high K\n +<\/jats:sup>\n concentration did not greatly differ between groups, indicating that arteries from spinalized rats were not generally hyperreactive. Sensitivity to the \u03b1\n 1<\/jats:sub>\n -adrenoceptor agonist phenylephrine was enhanced in arteries from spinalized rats, and the difference from controls was abolished by the norepinephrine uptake blocker desmethylimipramine. Sensitivity to the \u03b1\n 1<\/jats:sub>\n -adrenoceptor agonist methoxamine, which is not a substrate for the neuronal norepinephrine transporter, was similar among the groups. Thus the increased neurally evoked response after spinal transection appeared to be due to a reduction in neuronal uptake of released norepinephrine, a mechanism that did not explain the enhanced response of tail arteries after spinal transection that we previously reported. The findings provide further support for potentiated neurovascular responses contributing to the genesis of autonomic dysreflexia.\n <\/jats:p>","DOI":"10.1152\/ajpheart.00712.2005","type":"journal-article","created":{"date-parts":[[2005,9,2]],"date-time":"2005-09-02T21:13:35Z","timestamp":1125695615000},"page":"H398-H405","source":"Crossref","is-referenced-by-count":42,"title":["Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection"],"prefix":"10.1152","volume":"290","author":[{"given":"James A.","family":"Brock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Yeoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth M.","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.3.H969"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902830208"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017260"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01818891"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00166943"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01061.2002"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)34884-X"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168634"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702760"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705417"},{"key":"R11","unstructured":"Fleming WW\n and Westfall DP.\n Adaptive supersensitvity. In\n Handbook of Experimental Pharmacology: Catecholamines,\n edited by Trendelenburg\n u\n . 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