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By investigating interorgan pathologies, we uncovered multiple mechanisms of the S358L-induced disease, and these unique mechanisms likely appear to contribute to the disease pathogenesis. We hope our findings are important and novel and open new avenues in the hunting for additional diagnostic and therapeutic targets in subjects carrying TMEM43 mutation. <\/jats:p>","DOI":"10.1152\/ajpheart.00712.2022","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T15:29:14Z","timestamp":1682090954000},"page":"H866-H880","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The <i>TMEM43<\/i> S358L mutation affects cardiac, small intestine, and metabolic homeostasis in a knock-in mouse model"],"prefix":"10.1152","volume":"324","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7932-2237","authenticated-orcid":false,"given":"Buyan-Ochir","family":"Orgil","sequence":"first","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States"},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7241-9172","authenticated-orcid":false,"given":"Undral","family":"Munkhsaikhan","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4248-1290","authenticated-orcid":false,"given":"Joseph F.","family":"Pierre","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-2393","authenticated-orcid":false,"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States"},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis, Memphis, Tennessee, United States"},{"name":"Department of Cardiology, Second Affiliated Hospital, Harbin Medical University, Harbin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, United States"},{"name":"School of Pharmacy, Binzhou Medical University, Yantai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neely R.","family":"Alberson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States"},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States"},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn T.","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States"},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastiaan J. 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