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Better understanding of the cardiac metabolic phenotype and metabolic signaling could help identify the role metabolic remodeling plays within HF and the conditions known to transition toward HF, including \u201cpathological\u201d hypertrophy. In this review, we discuss metabolic phenotype and metabolic signaling in the contexts of pathological hypertrophy and HF. We discuss the significance of alterations in energy supply (substrate utilization, oxidative capacity, and phosphotransfer) and energy sensing using observations from human and animal disease models and models of manipulated energy supply\/sensing. We aim to provide ways of thinking about metabolic remodeling that center around metabolic flexibility, capacity (reserve), and efficiency rather than around particular substrate preferences or transcriptomic profiles. We show that maladaptive metabolic remodeling takes multiple forms across multiple energy-handling domains. We suggest that lack of metabolic flexibility and reserve (substrate, oxidative, and phosphotransfer) represents a final common denominator ultimately compromising efficiency and contractile reserve in stressful contexts. <\/jats:p>","DOI":"10.1152\/ajpheart.00731.2016","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T21:00:28Z","timestamp":1498251628000},"page":"H597-H616","source":"Crossref","is-referenced-by-count":79,"title":["Metabolic remodeling in hypertrophied and failing myocardium: a review"],"prefix":"10.1152","volume":"313","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1793-3128","authenticated-orcid":false,"given":"Mark A.","family":"Peterzan","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig 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