{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:17:15Z","timestamp":1793060235928,"version":"4.5.0"},"reference-count":42,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["R01 HL130513"],"award-info":[{"award-number":["R01 HL130513"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002003"],"award-info":[{"award-number":["UL1TR002003"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL141120"],"award-info":[{"award-number":["R01HL141120"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL073965"],"award-info":[{"award-number":["R01HL073965"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL083298"],"award-info":[{"award-number":["R01HL083298"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R56AG082099"],"award-info":[{"award-number":["R56AG082099"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p> Impairment of endothelial function under high blood pressure is linked to the loss of inwardly rectifying K<jats:sup>+<\/jats:sup> (Kir2.1) channels activity in human resistance arteries, leading to a reduction in flow-induced vasodilation and possibly leading to a vicious cycle between elevation of blood pressure, and further impairment of Kir2.1 function and flow-induced vasodilation. <\/jats:p>","DOI":"10.1152\/ajpheart.00732.2023","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T15:04:02Z","timestamp":1725030242000},"page":"H1004-H1015","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Impairment of microvascular endothelial Kir2.1 channels contributes to endothelial dysfunction in human hypertension"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-7062","authenticated-orcid":false,"given":"Natalia F.","family":"Do Couto","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, Allergy and Sleep, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States"},{"name":"Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, Illinois,United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-6755","authenticated-orcid":false,"given":"Ibra","family":"Fancher","sequence":"additional","affiliation":[{"name":"Department Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware, Newark, Delaware, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara T.","family":"Granados","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Cavalcante-Silva","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Beverley","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Allergy and Sleep, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-6980","authenticated-orcid":false,"given":"Sang Joon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Allergy and Sleep, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-4802","authenticated-orcid":false,"given":"Chueh-Lung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department Kinesiology, University of Texas at Arlington, Arlington, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane A.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, Illinois,United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Levitan","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Allergy and Sleep, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283437fcd"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.798958"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060247"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118623"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/21224"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83083"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1113\/JP273255"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.11"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2009"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/331168a0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00077.2005"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1113\/JP271652"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007430"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17672"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000218776.87842.43"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314935"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061649"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14254"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1021\/cb200146a"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3791\/59776"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00684.2016"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.197558"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.163576"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab330"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12154892"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4340"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqab018"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0808-2"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2012.00606.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090096"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-010-0118-2"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04540"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000079165.84309.4D"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.590614"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.897087"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0212-8"},{"key":"B37","doi-asserted-by":"crossref","unstructured":"Davis MJ, Hill MA, Kuo L. Local regulation of microvascular perfusion. In: Handbook of Physiology, section 2: The Cardiovascular System. Microcirculation, 2nd ed.; pt. 2, chapt. 6; Tuma, R.F., Duran, W.N., Ley, K., eds.; American Physiological Society: Maryland, MD, USA, 2008; pp. 161\u2013284.","DOI":"10.1016\/B978-0-12-374530-9.00006-1"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03649.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000158497.09626.3b"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100476"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00279.2023"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz275"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00732.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T18:55:00Z","timestamp":1727722500000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00732.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["10.1152\/ajpheart.00732.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00732.2023","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"assertion":[{"value":"2023-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}