{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:08:07Z","timestamp":1761581287039},"reference-count":32,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p> Individuals with spinal cord injuries above thoracic level 6 (T<jats:sub>6<\/jats:sub>) experience life-threatening bouts of hypertension, termed autonomic dysreflexia (AD). AD is mediated by peripheral \u03b1-adrenergic receptor supersensitivity as well as a reorganization of spinal pathways controlling sympathetic preganglionic neurons. A single bout of dynamic exercise may be a safe therapeutic approach to reduce the severity of AD because mild-to-moderate dynamic exercise reduces postexercise \u03b1-adrenergic receptor responsiveness, lowers postexercise sympathetic nerve activity, and reduces the postexercise response to stress. Therefore, this study was designed to test the hypothesis that mild-to-moderate dynamic exercise attenuates the postexercise response to colon distension (mechanism to elicit AD). To test this hypothesis, six male Wistar rats (406 \u00b1 23 g), 5 wk post-T<jats:sub>5<\/jats:sub> spinal cord transection, were instrumented with an arterial catheter. After recovery, the response to graded colon distension (10, 30, 50, and 80 mmHg, in random order) was determined before and after a single bout of mild-to-moderate dynamic exercise (9\u201312 m\/min, 0% grade for 40 min). After exercise, the pressor response to graded colon distension was significantly attenuated (preexercise change: 2 \u00b1 1, 9 \u00b1 1, 14 \u00b1 1, and 24 \u00b1 2 vs. postexercise change: 2 \u00b1 1, 2 \u00b1 1, 9 \u00b1 1, and 12 \u00b1 3 mmHg). Thus acute exercise is a safe, therapeutic approach to reduce the severity of AD in paraplegic subjects. <\/jats:p>","DOI":"10.1152\/ajpheart.00733.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:02:11Z","timestamp":1425412931000},"page":"H1566-H1570","source":"Crossref","is-referenced-by-count":27,"title":["Acute exercise reduces the response  to colon distension in T<sub>5<\/sub> spinal rats"],"prefix":"10.1152","volume":"282","author":[{"given":"Heidi L.","family":"Collins","sequence":"first","affiliation":[{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"Dicarlo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3100862"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.50.030188.002455"},{"key":"B4","first-page":"189","volume":"2","author":"Corbett JL","year":"1975","journal-title":"Clin Exp Pharmacol Physiol Suppl"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198610000-00008"},{"key":"B6","first-page":"248","volume":"74","author":"DeVivo MJ","year":"1993","journal-title":"Arch Phys Med Rehabil"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/62.4.456"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/68.1.40"},{"key":"B9","first-page":"A1151","volume":"15","author":"DiCarlo SE","year":"2001","journal-title":"FASEB J"},{"key":"B10","first-page":"17","volume":"5","author":"DiCarlo SE","year":"1994","journal-title":"Sports Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/63.7.1104"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-198500130-00010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/00003677-200104000-00005"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021592"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.6.2662"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199210000-00006"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1177\/036354657900700504"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.1.H27"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.4.H1090"},{"key":"B20","first-page":"18","volume":"40","author":"Lawson DM","year":"2001","journal-title":"Contemp Top Lab Anim Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01111-3"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.2.H625"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(83)90083-8"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1986.11699484"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90129-4"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb48356.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.256.3.R666"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.4.H1184"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.4.695"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3109\/10641969609097906"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0023"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.1.183"},{"key":"B36","first-page":"16","volume":"3","author":"Washburn RA","year":"1998","journal-title":"Topics Spinal Cord Injury Rehab"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00733.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:57:15Z","timestamp":1567969035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00733.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4,1]]}},"alternative-id":["10.1152\/ajpheart.00733.2001"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00733.2001","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}