{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:30:01Z","timestamp":1758702601844,"version":"3.37.3"},"reference-count":37,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Government | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-165817"],"award-info":[{"award-number":["PJT-165817"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:p> We developed a high-frequency ultrasound imaging protocol for diagnosing congenital aortic valve structural abnormalities in 4-wk-old mice. Our protocol defines specific criteria to distinguish mice with abnormal aortic valves from those with normal tricuspid valves using color Doppler, pulsed-wave Doppler, and two-dimensional (2-D) imaging with ultrahigh temporal resolution. This approach enables early identification of valvular abnormalities for efficient and ethical experimental design of longitudinal studies of congenital valve diseases and associated pathologies in mice. <\/jats:p>","DOI":"10.1152\/ajpheart.00769.2023","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T14:17:13Z","timestamp":1715955433000},"page":"H56-H66","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of congenital aortic valve malformations in juvenile natriuretic peptide receptor 2-deficient mice using high-frequency ultrasound"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1892-6836","authenticated-orcid":false,"given":"Vrushali","family":"Guruji","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada"},{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada"},{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1249-0548","authenticated-orcid":false,"given":"Mingyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, Ontario, Canada"},{"name":"Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, Ontario, Canada"},{"name":"Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada"},{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak","family":"Elbatarny","sequence":"additional","affiliation":[{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, Ontario, Canada"},{"name":"Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Physiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8099-8354","authenticated-orcid":false,"given":"Neda","family":"Latifi","sequence":"additional","affiliation":[{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, Ontario, Canada"},{"name":"Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Medical Engineering, University of South Florida, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7729-1772","authenticated-orcid":false,"given":"Craig A.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada"},{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, Ontario, Canada"},{"name":"Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-52672-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/children6050069"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.30.4.514"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.2021200496"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd5020021"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd2040248"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.802930"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1207059"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2016.01.017"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nature03940"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.02.041"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd2010017"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.04.001"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.11.012"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.05.009"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.67"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00392.2013"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311194"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00026.2004"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(02)00567-7"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3791\/54110"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000224114.65109.4e"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.068577"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2019.09.012"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00339.2017"},{"volume-title":"Summary and Analysis of Extension Program Evaluation in R","year":"2016","author":"Mangiafico SS","key":"B26"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2006.00358.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1177\/0300985819900018"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1075833"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309916"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd8080092"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1310"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003026"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027905.26586.E8"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/cc6975"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009827"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.740878"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00769.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T18:16:45Z","timestamp":1717957005000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00769.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7,1]]}},"alternative-id":["10.1152\/ajpheart.00769.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00769.2023","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"type":"print","value":"0363-6135"},{"type":"electronic","value":"1522-1539"}],"subject":[],"published":{"date-parts":[[2024,7,1]]},"assertion":[{"value":"2023-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}