{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:24:06Z","timestamp":1742383446724},"reference-count":28,"publisher":"American Physiological Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:p> Glycogen synthase kinase-3\u03b2 (GSK-3\u03b2) plays a central role in both cardiac physiology and pathology. Herein we want to clarify the role of GSK-3\u03b2 in familial dilated cardiomyopathy. We generated a mouse model carrying a heterozygous knockout mutation of GSK-3\u03b2 (GSK-3\u03b2<jats:sup>+\/\u2212<\/jats:sup> KO), together with a \u0394K210 knockin mutation in cardiac troponin T (\u0394K210 cTnT KI), which was proved to be one of the genetic causes of familial dilated cardiomyopathy (DCM). GSK-3\u03b2<jats:sup>+\/\u2212<\/jats:sup> KO prevented the slow and rapid deterioration in left ventricular systolic function accompanying heart failure (HF) in DCM mice with heterozygous and homozygous \u0394K210 cTnT KI mutations, respectively. GSK-3\u03b2<jats:sup>+\/\u2212<\/jats:sup> KO also prevented cardiac enlargement, myocardial fibrosis, and cardiomyocyte apoptosis and markedly reduced the expression of cardiac \u03b2-myosin heavy chain isoform, indicative of HF, in DCM mice with homozygous \u0394K210 cTnT KI mutation. GSK-3\u03b2<jats:sup>+\/\u2212<\/jats:sup> KO also extended the life span of these DCM mice. This study suggests that the inhibition of GSK-3\u03b2 is cardioprotective in familial DCM associated with \u0394K210 cTnT mutation. <\/jats:p>","DOI":"10.1152\/ajpheart.00771.2015","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T13:19:51Z","timestamp":1461935991000},"page":"H1808-H1815","source":"Crossref","is-referenced-by-count":8,"title":["GSK-3\u03b2 heterozygous knockout is cardioprotective in a knockin mouse model of familial dilated cardiomyopathy"],"prefix":"10.1152","volume":"310","author":[{"given":"Rasha M. S. M.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;"},{"name":"Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachio","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam A. A. E.-H.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Yun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Kun","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Arioka","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Takahashi-Yanaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Sasaguri","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00274.2002"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12098"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00610.2008"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/35096075"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00249.2012"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109718"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.106.146670"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302589"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.160614"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62023-7"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19906"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.197996"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012073432304"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36245"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003540"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01227.2004"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303613"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004968"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.08.006"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600633"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs105"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm084"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.022628899"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000152"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.277.2.C225"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00810.2013"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.211482"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401652"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00771.2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:47:30Z","timestamp":1567968450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00771.2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,6,1]]}},"alternative-id":["10.1152\/ajpheart.00771.2015"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00771.2015","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,1]]}}}