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Cold exposure delimited two periods: A ( days 1\u201310), with high systemic O<jats:sub>2<\/jats:sub> uptake and weight loss, and B ( days 10\u201330), with lower O<jats:sub>2<\/jats:sub> uptake and fat deposition. mtNOS activity and expression decreased in period A and then increased in period B by 60\u2013100% in liver and skeletal muscle ( P&lt; 0.05). Conversely, mitochondrial O<jats:sub>2<\/jats:sub> uptake remained initially high in the presence of l-arginine and later fell by 30\u201350% ( P &lt; 0.05). On this basis, the estimated fractional contribution of liver plus muscle to total BMR varied from 40% in period A to 25% in period B. The transitional modulation of mtNOS in rat cold acclimation could participate in adaptive responses that favor calorigenesis or conservative energy-saving mechanisms. <\/jats:p>","DOI":"10.1152\/ajpheart.00785.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:10:01Z","timestamp":1425413401000},"page":"H2375-H2383","source":"Crossref","is-referenced-by-count":24,"title":["Modulation of mitochondrial nitric oxide synthase  and energy expenditure in rats during cold acclimation"],"prefix":"10.1152","volume":"284","author":[{"given":"Jorge Guillermo","family":"Peralta","sequence":"first","affiliation":[{"name":"Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, 1120 Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola V.","family":"Finocchietto","sequence":"additional","affiliation":[{"name":"Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, 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