{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:30Z","timestamp":1787017650019,"version":"build-2736575974"},"reference-count":57,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    Clinical and experimental evidence has shown that myocardial ischemia activates cardiac spinal afferents that mediate sympathoexcitatory reflex responses. During myocardial ischemia, thromboxane A\n                    <jats:sub>2<\/jats:sub>\n                    (TxA\n                    <jats:sub>2<\/jats:sub>\n                    ) is released in large quantities by activated platelets in the coronary circulation of patients with coronary artery disease. We hypothesized that endogenous TxA\n                    <jats:sub>2<\/jats:sub>\n                    contributes to sympathoexcitatory reflexes during myocardial ischemia through stimulation of TxA\n                    <jats:sub>2<\/jats:sub>\n                    \/prostaglandin endoperoxide (TP) receptors. Regional myocardial ischemia was induced by occlusion of a diagonal branch of left anterior descending coronary artery of anesthetized cats. Hemodynamic parameters and renal sympathetic nerve activity were recorded after sinoaortic denervation and bilateral vagotomy. Regional myocardial ischemia evoked significant increases in mean blood pressure (122 \u00b1 10 vs. 139 \u00b1 12 mmHg, before vs. ischemia), aortic flow (153 \u00b1 18 vs. 167 \u00b1 20 ml\/min), first derivative of left ventricular pressure at 40-mmHg developed pressure (2,736 \u00b1 252 vs. 2,926 \u00b1 281 mmHg\/s), systemic vascular resistance (0.6 \u00b1 0.1 vs. 0.9 \u00b1 0.12 peripheral resistance units), and renal sympathetic nerve activity (by 22%). The reflex nature of the excitatory responses was confirmed by observing its disappearance after blockade of cardiac nerve transmission with intrapericardial 2% procaine treatment. Moreover, application of U-46619 (2.5\u201310 \u03bcg), a TxA\n                    <jats:sub>2<\/jats:sub>\n                    mimetic, on the heart caused graded increases in mean arterial pressure and renal nerve activity, responses that were abolished 3 min after local blockade of cardiac neural transmission with intrapericardial procaine. BM 13,177 (30 mg\/kg iv), a selective TP receptor antagonist, eliminated the reflex responses to U-46619 and significantly attenuated the excitatory responses during brief (5 min) regional myocardial ischemia. The sympathoexcitatory reflex responses to U-46619 were unchanged by blockade of histamine H\n                    <jats:sub>1<\/jats:sub>\n                    receptors with pyrilamine and serotonin 5-HT\n                    <jats:sub>3<\/jats:sub>\n                    receptors with tropisetron, indicating specificity of this TP receptor agonist. These data indicate that endogenous TxA\n                    <jats:sub>2<\/jats:sub>\n                    participates in myocardial ischemia-mediated sympathoexcitatory reflex responses through a TP receptor mechanism.\n                  <\/jats:p>","DOI":"10.1152\/ajpheart.00790.2008","type":"journal-article","created":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T20:44:56Z","timestamp":1224881096000},"page":"H2530-H2540","source":"Crossref","is-referenced-by-count":10,"title":["Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A\n                    <sub>2<\/sub>\n                    ?"],"prefix":"10.1152","volume":"295","author":[{"given":"Liang-Wu","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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Schwartz PJ, Zanchetti A.\n                      A sympathetic reflex elicited by experimental coronary occlusion.\n                      Am J Physiol\n                      217\n                      : 703\u2013709, 1969.","DOI":"10.1152\/ajplegacy.1969.217.3.703"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90691-4"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.44.1.47"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1982.243.3.R454"},{"key":"R33","unstructured":"Minisi AJ\n                      , Thames MD.\n                      Reflexes from ventricular receptors with vagal afferents. 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