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Sections recounting the evolution of knowledge about calcium-activated ion currents and calcium transient alternans are interspersed among sections describing the growth of the so-called \u201crestitution hypothesis,\u201d which involves time-dependent recovery of potassium channels (including their passage through pre-open states) as a function of diastolic interval. Major developments are generally in chronological order, but it is necessary to move back and forth between the two theories to respect the overall time line, which runs from about l965 to the present. The concluding two sections deal with the pathophysiology of calcium transient and APD alternans during ischemia, which may be the basis for out-of-hospital cardiac arrest during the initial stages of acute myocardial infarction. <\/jats:p>","DOI":"10.1152\/ajpheart.00802.2007","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T23:11:54Z","timestamp":1192835514000},"page":"H1-H10","source":"Crossref","is-referenced-by-count":87,"title":["Mechanisms of calcium transient and action potential alternans in cardiac cells and tissues"],"prefix":"10.1152","volume":"294","author":[{"given":"William T.","family":"Clusin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000244087.36230.bf"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011583"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Bers DM. 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