{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:38:55Z","timestamp":1791247135672,"version":"4.1.0"},"reference-count":62,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>The influence of sickle cell trait and\/or \u03b1-thalassemia on skeletal muscle microvascular network characteristics was assessed and compared with control subjects [hemoglobin (Hb) AA] in 30 Cameroonian residents [10 HbAA, 5 HbAA \u03b1-thalassemia (\u03b1-t), 6 HbAS, and 9 HbAS\u03b1-t] matched for maximal work capacity and daily energy expenditure. Subjects performed an incremental exercise to exhaustion and underwent a muscle biopsy. Muscle fiber type and surface area were not different among groups. However, sickle cell trait (SCT) was associated with lower capillary density ( P &lt; 0.05), lower capillary tortuosity ( P &lt; 0.001), and enlarged microvessels ( P &lt; 0.01). SCT carriers had reduced counts of microvessels &lt;5-\u03bcm diameter, but a higher percentage of broader microvessels, i.e., diameter &gt;10 \u03bcm ( P &lt; 0.05). \u03b1-Thalassemia seemed to be characterized by a higher capillary tortuosity and unchanged capillary density and diameter. Thus, while SCT is a priori clinically benign, we demonstrate for the first time that significant remodeling of the microvasculature occurs in SCT carriers. These modifications may possibly reflect protective adaptations against hemorheological and microcirculatory dysfunction induced by the presence of HbS. The remodeling of the microvascular network occurs to a lesser extent in \u03b1-thalassemia. In \u03b1-thalassemic subjects, increased capillary tortuosity would promote oxygen supply to muscle tissues and might compensate for the lower Hb content often reported in those subjects.<\/jats:p>","DOI":"10.1152\/ajpheart.00812.2009","type":"journal-article","created":{"date-parts":[[2009,11,14]],"date-time":"2009-11-14T03:15:15Z","timestamp":1258168515000},"page":"H375-H384","source":"Crossref","is-referenced-by-count":44,"title":["Remodeling of skeletal muscle microvasculature in sickle cell trait and \u03b1-thalassemia"],"prefix":"10.1152","volume":"298","author":[{"given":"Lucile","family":"Vincent","sequence":"first","affiliation":[{"name":"Laboratoire de Physiologie de l'Exercice, Universit\u00e9 de Savoie, Chamb\u00e9ry;"},{"name":"Institut F\u00e9d\u00e9ratif de Recherche en Sciences et Ing\u00e9nierie de la Sant\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9onard","family":"F\u00e9asson","sequence":"additional","affiliation":[{"name":"Institut F\u00e9d\u00e9ratif de Recherche en Sciences et Ing\u00e9nierie de la Sant\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, and"},{"name":"Laboratoire de Physiologie de l'Exercice, Universit\u00e9 Jean Monnet, and"},{"name":"Unit\u00e9 de Myologie, Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Oyono-Engu\u00e9ll\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Banimbek","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Denis","sequence":"additional","affiliation":[{"name":"Institut F\u00e9d\u00e9ratif de Recherche en Sciences et Ing\u00e9nierie de la Sant\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, and"},{"name":"Laboratoire de Physiologie de l'Exercice, Universit\u00e9 Jean Monnet, and"},{"name":"Unit\u00e9 de Myologie, Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Guarneri","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie de l'Exercice, Universit\u00e9 Jean Monnet, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Aufradet","sequence":"additional","affiliation":[{"name":"Centre de Recherche et d'Innovation sur le Sport, EA 647, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Monchanin","sequence":"additional","affiliation":[{"name":"Centre de Recherche et d'Innovation sur le Sport, EA 647, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Martin","sequence":"additional","affiliation":[{"name":"Centre de Recherche et d'Innovation sur le Sport, EA 647, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gozal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois; 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