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Fetal exposure to SSRIs is associated with persistent pulmonary hypertension of the newborn (PPHN); however, a direct link between the two has yet to be established. Conversely, it is well known that PPHN can be caused by premature constriction of the ductus arteriosus (DA), a fetal vessel connecting the pulmonary and systemic circulations. We hypothesized that SSRIs could induce in utero DA constriction. Using isolated vessels and whole-animal models, we sought to determine the effects of two commonly prescribed SSRIs, fluoxetine and sertraline, on the fetal mouse DA. Cannulated vessel myography studies demonstrated that SSRIs caused concentration-dependent DA constriction and made vessels less sensitive to prostaglandin-induced dilation. Moreover, in vivo studies showed that SSRI-exposed mice had inappropriate DA constriction in utero. Taken together, these findings establish that SSRIs promote fetal DA constriction and provide a potential mechanism by which SSRIs could contribute to PPHN.<\/jats:p>","DOI":"10.1152\/ajpheart.00822.2015","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T02:15:59Z","timestamp":1467425759000},"page":"H572-H581","source":"Crossref","is-referenced-by-count":31,"title":["Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero"],"prefix":"10.1152","volume":"311","author":[{"given":"Christopher W.","family":"Hooper","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassidy","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Denver, 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