{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:15:11Z","timestamp":1770218111794,"version":"3.49.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:p> Depressed parasympathetic tone is associated with an increased risk of sudden cardiac death. Exercise and the postexercise recovery period, which are associated with parasympathetic withdrawal, are high risk periods for sudden death. However, parasympathetic effects on cardiac electrophysiology during exercise and recovery have not been described. Electrophysiology studies were performed using noninvasive programmed stimulation (NIPS) in nine subjects (age 59 \u00b1 18 yr) with implanted dual-chamber devices and normal left ventricular function during multiple bicycle exercise sessions. NIPS was performed at rest, during exercise, and in the early recovery period both before and after parasympathetic blockade with atropine. Parasympathetic effect was defined as the value of the parameter of interest in the absence of atropine minus the value of the parameter in the presence of atropine. During exercise, sinus cycle length, atrioventricular (AV) block cycle length, AV interval, and ventricular effective refractory period shortened; in recovery, the values were intermediate between the rest and exercise values ( P &lt; 0.0001 by ANOVA). Parasympathetic effects on sinus cycle length, AV block cycle length, AV interval, and ventricular effective refractory period were 247 \u00b1 140, 58 \u00b1 20, 76 \u00b1 20, and 8.6 \u00b1 7.5 ms at rest, 106 \u00b1 20, 37 \u00b1 14, 24 \u00b1 13, and 2.6 \u00b1 7.8 ms during exercise, and 209 \u00b1 114, 50 \u00b1 23, 35 \u00b1 21, and 9.5 \u00b1 11.8 ms during recovery, respectively. There was poor correlation among the parasympathetic effects noted at the sinus node, AV node, and ventricle. Further work evaluating parasympathetic effects on cardiac electrophysiology during exercise and recovery in patients with heart disease is required to elucidate its role in modulating the risk of sudden cardiac death noted at these times. <\/jats:p>","DOI":"10.1152\/ajpheart.00825.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:03:02Z","timestamp":1425394982000},"page":"H2091-H2098","source":"Crossref","is-referenced-by-count":62,"title":["Parasympathetic effects on cardiac electrophysiology  during exercise and recovery"],"prefix":"10.1152","volume":"282","author":[{"given":"Prince J.","family":"Kannankeril","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Northwestern University, Chicago, Illinois 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Goldberger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, 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