{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:58:26Z","timestamp":1781762306699,"version":"3.54.5"},"reference-count":25,"publisher":"American Physiological Society","issue":"7","funder":[{"name":"National Development Agency of Hungary","award":["TAMOP-4.2.2\/B-10\/1-2010-0013"],"award-info":[{"award-number":["TAMOP-4.2.2\/B-10\/1-2010-0013"]}]},{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok (Hungarian Scientific Research Fund)","doi-asserted-by":"publisher","award":["OTKA 105555"],"award-info":[{"award-number":["OTKA 105555"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia (Hungarian Academy of Sciences)","doi-asserted-by":"publisher","award":["Janos Bolyai Research Scholarship"],"award-info":[{"award-number":["Janos Bolyai Research Scholarship"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:p>Contractile function is considered to be precisely measurable only by invasive hemodynamics. We aimed to correlate strain values measured by speckle-tracking echocardiography (STE) with sensitive contractility parameters of pressure-volume (P-V) analysis in a rat model of exercise-induced left ventricular (LV) hypertrophy. LV hypertrophy was induced in rats by swim training and was compared with untrained controls. Echocardiography was performed using a 13-MHz linear transducer to obtain LV long- and short-axis recordings for STE analysis (GE EchoPAC). Global longitudinal (GLS) and circumferential strain (GCS) and longitudinal (LSr) and circumferential systolic strain rate (CSr) were measured. LV P-V analysis was performed using a pressure-conductance microcatheter, and load-independent contractility indices [slope of the end-systolic P-V relationship (ESPVR), preload recruitable stroke work (PRSW), and maximal dP\/d t-end-diastolic volume relationship (dP\/d t<jats:sub>max<\/jats:sub>-EDV)] were calculated. Trained rats had increased LV mass index (trained vs. control; 2.76 \u00b1 0.07 vs. 2.14 \u00b1 0.05 g\/kg, P &lt; 0.001). P-V loop-derived contractility parameters were significantly improved in the trained group (ESPVR: 3.58 \u00b1 0.22 vs. 2.51 \u00b1 0.11 mmHg\/\u03bcl; PRSW: 131 \u00b1 4 vs. 104 \u00b1 2 mmHg, P &lt; 0.01). Strain and strain rate parameters were also supernormal in trained rats (GLS: \u221218.8 \u00b1 0.3 vs. \u221215.8 \u00b1 0.4%; LSr: \u22125.0 \u00b1 0.2 vs. \u22124.1 \u00b1 0.1 Hz; GCS: \u221218.9 \u00b1 0.8 vs. \u221214.9 \u00b1 0.6%; CSr: \u22124.9 \u00b1 0.2 vs. \u22123.8 \u00b1 0.2 Hz, P &lt; 0.01). ESPVR correlated with GLS ( r = \u22120.71) and LSr ( r = \u22120.53) and robustly with GCS ( r = \u22120.83) and CSr ( r = \u22120.75, all P &lt; 0.05). PRSW was strongly related to GLS ( r = \u22120.64) and LSr ( r = \u22120.71, both P &lt; 0.01). STE can be a feasible and useful method for animal experiments. In our rat model, strain and strain rate parameters closely reflected the improvement in intrinsic contractile function induced by exercise training.<\/jats:p>","DOI":"10.1152\/ajpheart.00828.2014","type":"journal-article","created":{"date-parts":[[2015,1,24]],"date-time":"2015-01-24T03:44:50Z","timestamp":1422071090000},"page":"H743-H748","source":"Crossref","is-referenced-by-count":74,"title":["Strain and strain rate by speckle-tracking echocardiography correlate with pressure-volume loop-derived contractility indices in a rat model of athlete's heart"],"prefix":"10.1152","volume":"308","author":[{"given":"Attila","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, Budapest, 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