{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:06:01Z","timestamp":1778717161717,"version":"3.51.4"},"reference-count":43,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p>Cl<jats:sup>\u2212<\/jats:sup>efflux induces depolarization and contraction of smooth muscle cells. This study was undertaken to explore the role of Cl<jats:sup>\u2212<\/jats:sup>flux in histamine-induced contraction in the rabbit basilar artery. Male New Zealand White rabbits ( n = 16) weighing 1.8\u20132.5 kg were euthanized by an overdose of pentobarbital sodium. The basilar arteries were removed for isometric tension recording. Histamine produced a concentration-dependent contraction that was attenuated by the H<jats:sub>1<\/jats:sub>receptor antagonist chlorpheniramine (10<jats:sup>\u22128<\/jats:sup>M) but not by the H<jats:sub>2<\/jats:sub>receptor antagonist cimetidine (3 \u00d7 10<jats:sup>\u22126<\/jats:sup>M) in normal Cl<jats:sup>\u2212<\/jats:sup>Krebs-Henseleit bicarbonate solution (123 mM Cl<jats:sup>\u2212<\/jats:sup>). The histamine-induced contraction was reduced by the following manipulations: 1) inhibition of Na<jats:sup>+<\/jats:sup>-K<jats:sup>+<\/jats:sup>-2Cl<jats:sup>\u2212<\/jats:sup>cotransporter with bumetanide (3 \u00d7 10<jats:sup>\u22125<\/jats:sup>and 10<jats:sup>\u22124<\/jats:sup>M), 2) bicarbonate-free HEPES solution to disable Cl<jats:sup>\u2212<\/jats:sup>\/HCO[Formula: see text] exchanger, and 3) blockade of Cl<jats:sup>\u2212<\/jats:sup>channels with the use of niflumic acid, 5-nitro-2-(3-phenylpropylamino) benzoic acid, and indoleacetic acid 94 R-(+)-methylindazone. In addition, substitution of extracellular Cl<jats:sup>\u2212<\/jats:sup>(10 mM) with methanesulfonate acid (113 mM) transiently enhanced histamine-induced contraction. Manipulation of Cl<jats:sup>\u2212<\/jats:sup>flux affects histamine-induced contraction in the rabbit basilar artery.<\/jats:p>","DOI":"10.1152\/ajpheart.00837.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:02:11Z","timestamp":1425412931000},"page":"H1427-H1436","source":"Crossref","is-referenced-by-count":14,"title":["Manipulation of chloride flux affects histamine-induced contraction in rabbit basilar artery"],"prefix":"10.1152","volume":"282","author":[{"given":"Yun","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi 39216"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi 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