{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:23:04Z","timestamp":1780464184319,"version":"3.54.1"},"reference-count":33,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p> This study investigates whether hyperemic microvascular resistance (MR) is influenced by elective percutaneous coronary intervention (PCI) by using the index of microcirculatory resistance (IMR). Seventy-one consecutive patients with stable angina pectoris undergoing elective PCI were prospectively studied. The IMR was measured before and after PCI and at the 10-mo follow-up. The IMR significantly decreased until follow-up; the pre-PCI, post-PCI, and follow-up IMRs had a median of 19.8 (interquartile range, 14.6\u201328.9), 16.2 (11.8\u201322.1), and 14.8 (11.8\u201318.7), respectively ( P &lt; 0.001). The pre-PCI IMR was significantly correlated with the change in IMR between pre- and post-PCI ( r = 0.84, P &lt; 0.001) and between pre-PCI and follow-up ( r = 0.93, P &lt; 0.001). Pre-PCI IMR values were significantly higher in territories with decreases in IMR than in those with increases in IMR [pre-PCI IMR: 25.4 (18.4\u201335.5) vs. 12.5 (9.4\u201316.8), P &lt; 0.001]. At follow-up, IMR values in territories showing decreases in IMR were significantly lower than those with increases in IMR [IMR at follow-up: 13.9 (10.9\u201317.6) vs. 16.6 (14.0\u201321.4), P = 0.013]. The IMR decrease was significantly associated with a greater shortening of mean transit time, indicating increases in coronary flow ( P &lt; 0.001). The optimal cut-off values of pre-PCI IMR to predict a decrease in IMR after PCI and at follow-up were 16.8 and 17.0, respectively. In conclusion, elective PCI affected hyperemic MR and its change was associated with pre-PCI MR, resulting in showing a wide distribution. Overall hyperemic MR significantly decreased until follow-up. The modified hyperemic MR introduced by PCI may affect post-PCI coronary flow. <\/jats:p>","DOI":"10.1152\/ajpheart.00837.2015","type":"journal-article","created":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T06:05:21Z","timestamp":1466921121000},"page":"H520-H531","source":"Crossref","is-referenced-by-count":20,"title":["The influence of elective percutaneous coronary intervention on microvascular resistance: a serial assessment using the index of microcirculatory resistance"],"prefix":"10.1152","volume":"311","author":[{"given":"Tadashi","family":"Murai","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, Japan; and"},{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsumin","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, Japan; 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