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To evaluate this concept of endogenous mineralocorticoids in Wistar rats post-MI, we examined effects of blockade of MR and Na<jats:sup>+<\/jats:sup> channels in the brain. At 3 days after coronary artery ligation, intracerebroventricular infusions were started with spironolactone (400 ng\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>) or its vehicle, or with benzamil (4 \u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>) or its vehicle, using osmotic minipumps. Rats with sham ligation served as control. After 4 wk, in conscious rats, mean arterial pressure, heart rate, and renal sympathetic nerve activity were recorded at rest and in response to air-jet stress, intracerebroventricular injection of the \u03b1<jats:sub>2<\/jats:sub>-adrenoceptor agonist guanabenz, and intravenous infusion of phenylephrine and nitroprusside for baroreflex function. MI size was similar among the four groups of rats (\u223c31%). In rats treated post-MI with vehicles, cardiac function was decreased, sympathetic reactivity was enhanced, and baroreflex function was impaired. Blockade of brain Na<jats:sup>+<\/jats:sup> channels or brain MR similarly prevented sympathetic hyperactivity and impairment of baroreflex function and improved cardiac function. These findings suggest that in rats post-MI, increased binding of endogenous agonists to MR increases ENaC activity in the brain and thereby leads to sympathetic hyperactivity and progressive left ventricular dysfunction. <\/jats:p>","DOI":"10.1152\/ajpheart.00840.2004","type":"journal-article","created":{"date-parts":[[2004,12,23]],"date-time":"2004-12-23T01:24:16Z","timestamp":1103765056000},"page":"H2491-H2497","source":"Crossref","is-referenced-by-count":46,"title":["Blockade of brain mineralocorticoid receptors or Na<sup>+<\/sup> channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI"],"prefix":"10.1152","volume":"288","author":[{"given":"Bing S.","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans H. 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