{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:19:56Z","timestamp":1793089196324,"version":"4.5.0"},"reference-count":63,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p> Advancing age is a major risk factor for coronary artery disease. Endothelial dysfunction accompanied by increased oxidative stress and inflammation with aging may predispose older arteries to greater ischemia-reperfusion (I\/R) injury. Because coronary artery ischemia cannot be induced safely, the effects of age and habitual endurance exercise on endothelial I\/R injury have not been determined in humans. Using the brachial artery as a surrogate model of the coronary arteries, endothelial function, assessed by brachial artery flow-mediated dilation (FMD), was measured before and after 20 min of continuous forearm occlusion in young sedentary ( n = 10, 24 \u00b1 2 yr) and middle-aged ( n = 9, 48 \u00b1 2 yr) sedentary adults to gain insight into the effects of primary aging on endothelial I\/R injury. Young ( n = 9, 25 \u00b1 1 yr) and middle-aged endurance-trained ( n = 9, 50 \u00b1 2 yr) adults were also studied to determine whether habitual exercise provides protection from I\/R injury. Fifteen minutes after ischemic injury, FMD decreased significantly by 37% in young sedentary, 35% in young endurance-trained, 68% in middle-aged sedentary, and 50% in middle-aged endurance-trained subjects. FMD returned to baseline levels within 30 min in young sedentary and endurance-trained subjects but remained depressed in middle-aged sedentary and endurance-trained subjects. Circulating markers of antioxidant capacity and inflammation were not related to FMD. In conclusion, advancing age is associated with a greater magnitude and delayed recovery from endothelial I\/R injury in humans. Habitual endurance exercise may provide partial protection to the endothelium against this form of I\/R injury with advancing age. <\/jats:p>","DOI":"10.1152\/ajpheart.00845.2010","type":"journal-article","created":{"date-parts":[[2011,1,15]],"date-time":"2011-01-15T03:24:03Z","timestamp":1295061843000},"page":"H813-H819","source":"Crossref","is-referenced-by-count":37,"title":["Endothelial ischemia-reperfusion injury in humans: association with age and habitual exercise"],"prefix":"10.1152","volume":"300","author":[{"given":"Allison E.","family":"DeVan","sequence":"first","affiliation":[{"name":"Cardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Umpierre","sequence":"additional","affiliation":[{"name":"Cardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, The University of Texas at 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