{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:24:06Z","timestamp":1773048246556,"version":"3.50.1"},"reference-count":26,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p> The exact role of arousal in central and peripheral hemodynamic responses to passive limb movement in humans is unclear but has been proposed as a potential contributor. Thus, we used a human model with no lower limb afferent feedback to determine the role of arousal on the hemodynamic response to passive leg movement. In nine people with a spinal cord injury, we compared central and peripheral hemodynamic and ventilatory responses to one-leg passive knee extension with and without visual feedback (M+VF and M-VF, respectively) as well as in a third trial with no movement or visual feedback but the perception of movement (F). Ventilation (V\u0307e), heart rate, stroke volume, cardiac output, mean arterial pressure, and leg blood flow (LBF) were evaluated during the three protocols. V\u0307e increased rapidly from baseline in M+VF (55 \u00b1 11%), M-VF (63 \u00b1 13%), and F (48 \u00b1 12%) trials. Central hemodynamics (heart rate, stroke volume, cardiac output, and mean arterial pressure) were unchanged in all trials. LBF increased from baseline by 126 \u00b1 18 ml\/min in the M+VF protocol and 109 \u00b1 23 ml\/min in the M-VF protocol but was unchanged in the F protocol. Therefore, with the use of model that is devoid of afferent feedback from the legs, the results of this study reveal that, although arousal is invoked by passive movement or the thought of passive movement, as evidenced by the increase in V\u0307e, there is no central or peripheral hemodynamic impact of this increased neural activity. Additionally, this study revealed that a central hemodynamic response is not an obligatory component of movement-induced LBF. <\/jats:p>","DOI":"10.1152\/ajpheart.00851.2011","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T22:54:56Z","timestamp":1318632896000},"page":"H333-H339","source":"Crossref","is-referenced-by-count":22,"title":["Central and peripheral hemodynamic responses to passive limb movement: the role of arousal"],"prefix":"10.1152","volume":"302","author":[{"given":"Massimo","family":"Venturelli","sequence":"first","affiliation":[{"name":"Department of Neurological, Neuropsychological, Morphological, and Movement Sciences University of Verona, Verona, Italy;"},{"name":"Division of Geriatrics, Department of Medicine, University of Utah, Salt Lake City;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Amann","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine, University of Utah, Salt Lake City;"},{"name":"Geriatric Research, Education, and Clinical Center, George E. Whalen Veterans Affairs Medical Center, Salt Lake City; and"},{"name":"Department of Exercise and Sport Science, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"McDaniel","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine, University of Utah, Salt Lake City;"},{"name":"Geriatric Research, Education, and Clinical Center, George E. Whalen Veterans Affairs Medical Center, Salt Lake City; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Trinity","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine, University of Utah, Salt Lake City;"},{"name":"Geriatric Research, Education, and Clinical Center, George E. Whalen Veterans Affairs Medical Center, Salt Lake City; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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