{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:52Z","timestamp":1787017672099,"version":"build-2736575974"},"reference-count":50,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100012166","name":"Shanghai Pujiang program","doi-asserted-by":"publisher","award":["19PJ1408900"],"award-info":[{"award-number":["19PJ1408900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Development Fund of Shanghai Pudong New Area","award":["PKJ2020-Y23"],"award-info":[{"award-number":["PKJ2020-Y23"]}]},{"name":"Science and Technology Committee of Shanghai Municipality","award":["17431906600"],"award-info":[{"award-number":["17431906600"]}]},{"name":"MOST | National Key Research and Development Program of China","award":["2017YFA0105600"],"award-info":[{"award-number":["2017YFA0105600"]}]},{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0112600"],"award-info":[{"award-number":["2020YFA0112600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870208"],"award-info":[{"award-number":["81870208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070260"],"award-info":[{"award-number":["82070260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:p>NGF PLGA nanoparticles can exert a protective effect on hUCMSCs and promote the paracrine effects of hUCMSCs on angiogenesis and cardiomyocyte protection through TrkA-PI3K\/Akt signaling pathway, the same with free NGF. The application of NGF PLGA nanoparticles in the hUCMSC fibrin cardiac patches can significantly improve the retention of transplanted hUCMSCs and enhance their ability to reduce myocardial apoptosis and promote angiogenesis in the mouse heart after MI.<\/jats:p>","DOI":"10.1152\/ajpheart.00855.2020","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T12:22:57Z","timestamp":1616761377000},"page":"H1959-H1974","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["NGF nanoparticles enhance the potency of transplanted human umbilical cord mesenchymal stem cells for myocardial repair"],"prefix":"10.1152","volume":"320","author":[{"given":"Wei","family":"Luo","sequence":"first","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"},{"name":"Department of Cardiovascular and Thoracic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"Gong","sequence":"additional","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"},{"name":"Department of Cardiovascular and Thoracic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Jia","sequence":"additional","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"},{"name":"Department of Cardiovascular and Thoracic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"},{"name":"Shanghai Institute of Stem Cell Research and Clinical translation, Shanghai East Hospital, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-6724","authenticated-orcid":false,"given":"Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"},{"name":"Shanghai Institute of Stem Cell Research and Clinical translation, Shanghai East Hospital, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7045245"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.117.310712"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1802-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0697-9"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103236"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061143"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x16666180412092859"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095190"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.180743"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.05.001"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-019-03518-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.001"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.01.011"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00471.2017"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29325"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801690r"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.030785"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2016-0079"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.310277"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.000025"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.118.313094"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.11.009"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1021\/ar200113c"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/nano8040243"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10020057"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.000366"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr435"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.04.052"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2017.08.004"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.2995"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-02011-z"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040982"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.118.311213"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2018_309"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x13666150403231920"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.141"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.208"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.12.017"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.109.210088"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00617.2012"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161629"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00964"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00180.2019"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m108989200"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1436-0"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.04.008"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.010"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nm0405-367"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.186742"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.10.071"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00855.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T05:33:19Z","timestamp":1624426399000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00855.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,1]]}},"alternative-id":["10.1152\/ajpheart.00855.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00855.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"2020-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}