{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:49:56Z","timestamp":1761580196635},"reference-count":31,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p> In the brain, ouabain-like compounds (OLC) and the reninangiotensin system (RAS) contribute to sympathetic hyperactivity in rats after myocardial infarction (MI). This study aimed to evaluate changes in components of the central vs. the peripheral RAS. Angiotensin-converting enzyme (ACE) and angiotensin type 1 (AT<jats:sub>1<\/jats:sub>) receptor binding densities were determined by measuring <jats:sup>125<\/jats:sup>I-labeled 351A and <jats:sup>125<\/jats:sup>I-labeled ANG II binding 4 and 8 wk after MI. In the brain, ACE and AT<jats:sub>1<\/jats:sub> receptor binding increased 8\u201315% in the subfornical organ, 14\u201322% in the organum vasculosum laminae terminalis, 20\u201334% in the paraventricular nucleus, and 13\u201315% in the median preoptic nucleus. In the heart, the greatest increase in ACE and AT<jats:sub>1<\/jats:sub> receptor binding occurred at the infarct scar (\u223c10-fold) and the least in the right ventricle (2-fold). In kidneys, ACE and AT<jats:sub>1<\/jats:sub> receptor binding decreased 10\u201315%. After intracerebroventricular infusion of Fab fragments to block brain OLC from 0.5 to 4 wk after MI, increases in ACE and AT<jats:sub>1<\/jats:sub> receptors in the subfornical organ, organum vasculosum laminae terminalis, paraventricular nucleus, and medial preoptic nucleus were markedly inhibited, and ACE and AT<jats:sub>1<\/jats:sub> receptor densities in the heart increased less (6-fold in the infarct scar). In kidneys, decreases in ACE and AT<jats:sub>1<\/jats:sub> receptor binding were absent after treatment with Fab fragments. These results demonstrate that ACE and AT<jats:sub>1<\/jats:sub> receptor binding densities increase not only in the heart but also in relevant areas of the brain of rats after MI. Brain OLC appears to play a major role in activation of brain RAS in rats after MI and, to a modest degree, in activation of the cardiac RAS. <\/jats:p>","DOI":"10.1152\/ajpheart.00858.2003","type":"journal-article","created":{"date-parts":[[2004,4,8]],"date-time":"2004-04-08T19:05:21Z","timestamp":1081451121000},"page":"H1665-H1671","source":"Crossref","is-referenced-by-count":55,"title":["Increases in brain and cardiac AT<sub>1<\/sub> receptor and ACE densities after myocardial infarct in rats"],"prefix":"10.1152","volume":"286","author":[{"given":"Junhui","family":"Tan","sequence":"first","affiliation":[{"name":"Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans H. H.","family":"Leenen","sequence":"additional","affiliation":[{"name":"Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00249-6"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.6.1572"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03658.x"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00711461"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1994.266.1.R27"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.3.261"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.2.137"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.0335.2000"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.1.H103"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920455"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.5.993"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.1.H317"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.209"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.5.H1786"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65037-7"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.6.H2664"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.2.137"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.4.R1095"},{"key":"REF19","unstructured":"Paxinos GA and Watson WC. 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