{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:15:59Z","timestamp":1790435759095,"version":"4.1.0"},"reference-count":58,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100008460","name":"HHS | NIH | National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R00 AT010017"],"award-info":[{"award-number":["R00 AT010017"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>We observed major vascular physiological differences between C57BL\/6J and C57BL\/6N mice, indicating C57BL\/6N mice have greater vascular function. However, in comparison to either C57BL\/6 substrain, outbred, genetically diverse UM-HET3 mice have a greater vascular function characterized by lower aortic stiffness and greater endothelial-dependent dilation. A greater vascular function in UM-HET3 mice was not accompanied by more measurement variability, as coefficient of variation across measurements was similar between strains.<\/jats:p>","DOI":"10.1152\/ajpheart.00863.2025","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T16:51:03Z","timestamp":1766595063000},"page":"H406-H414","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Inbred C57BL\/6J and C57BL\/6N mice exhibit differential vascular dysfunction compared with outbred UM-HET3 mice"],"prefix":"10.1152","volume":"330","author":[{"given":"Mostafa","family":"Sabouri","sequence":"first","affiliation":[{"name":"Florida State University","place":["United States"]},{"name":"University of New Mexico School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-2172","authenticated-orcid":false,"given":"Xiangyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Florida State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan J.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Florida State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoxin","family":"Li","sequence":"additional","affiliation":[{"name":"Florida State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Berg Sen","sequence":"additional","affiliation":[{"name":"Florida State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Florida State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-4686","authenticated-orcid":false,"given":"Daniel R.","family":"Machin","sequence":"additional","affiliation":[{"name":"Florida State University","place":["United States"]},{"name":"University of New Mexico School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2192"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.161"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-7-r82"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.10.001"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/71641"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153472"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.12.002"},{"key":"B8","doi-asserted-by":"publisher","unstructured":"Guzniczak N, Makuch M, Tillett M, Bagavant H, Deshmukh US. Aging-associated autoimmunity in genetically diverse UM-HET3 mice shows a female sex bias (Preprint). bioRxiv 2025.2007.2025.666876, 2025. doi:10.1101\/2025.07.25.666876.","DOI":"10.1101\/2025.07.25.666876"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-024-03349-y"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa285"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo3191"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13328"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.03.008"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01176-2"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz069"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70255"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/alz.095615"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00031.2014"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.11.038"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01226-9"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3109\/10641969809052120"},{"key":"B22","unstructured":"National Research Council (U.S.), Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research (U.S.), and National Academies Press (U.S.). Guide for the Care and Use of Laboratory Animals. National Academies Press, 2011, p. xxv, 220."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb01291.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04147"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.301"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2011.635231"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103322"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39466-x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00415.2022"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1090023"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00885.2020"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70384"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00491.2025"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2019.33.1_supplement.525.6"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/JP289322"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00242.2024"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.05.025"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg299"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.12.050"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/biom12081125"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00856"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.11.005"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00716.2015"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-00745-1"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.88.6.593"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00410.2010"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.536805"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00337.2023"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00541.2008"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00691.2002"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02006.x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1159\/000338747"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.74"},{"key":"B54","first-page":"37","volume-title":"Development of the Rodent as a Model System of Aging","author":"Russell ES","year":"1978"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0224-7"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41437-020-00361-1"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.08.013"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00656.2021"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00863.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:16:40Z","timestamp":1768396600000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00863.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/ajpheart.00863.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00863.2025","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}