{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:18:54Z","timestamp":1790828334897,"version":"4.1.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["937990"],"award-info":[{"award-number":["937990"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002537"],"award-info":[{"award-number":["UL1TR002537"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>To our knowledge, this is the first study to demonstrate that chronic antidepressant use is associated with preserved endothelial function in women with a history of preeclampsia (hxPE). Compared with healthy controls, untreated women with hxPE had reduced macrovascular (brachial artery) and microvascular (cutaneous) endothelial function, whereas those treated with antidepressants exhibited preserved endothelial function. These findings suggest that antidepressants may modulate persistent endothelial dysfunction in these women following preeclampsia.<\/jats:p>","DOI":"10.1152\/ajpheart.00890.2025","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:31:01Z","timestamp":1768408261000},"page":"H524-H530","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Vascular endothelial function is preserved in women with a history of preeclampsia currently receiving antidepressant pharmacotherapy"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-5903","authenticated-orcid":false,"given":"Ruda","family":"Lee","sequence":"first","affiliation":[{"name":"University of Iowa","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9855-3978","authenticated-orcid":false,"given":"Jody L.","family":"Greaney","sequence":"additional","affiliation":[{"name":"University of Delaware","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-8017","authenticated-orcid":false,"given":"Mark K.","family":"Santillan","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7499-080X","authenticated-orcid":false,"given":"Gary L.","family":"Pierce","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["United States"]},{"name":"University of Iowa","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-3879","authenticated-orcid":false,"given":"Anna E.","family":"Stanhewicz","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a45b25"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09246"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09386"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0272-9"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaf033"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12175"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.08.007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10010056"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2174\/1567202613666160226152549"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.121"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.04.024"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313764"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-01065-z"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000142303.49306.0d"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2021.0328"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/abm\/kaad015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00471.2010"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1089\/whr.2022.0062"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000012543.55874.47"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.041"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2346"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3109\/08037050903289606"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2013.4623"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.09.002"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.10.010"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04857.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9070781"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.02.012"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00670-0"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.12.007"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2019.31.14-18"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00890.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T19:31:58Z","timestamp":1769542318000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00890.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/ajpheart.00890.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00890.2025","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}