{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T05:29:21Z","timestamp":1794461361787,"version":"4.9.1"},"reference-count":215,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","award":["2022060878"],"award-info":[{"award-number":["2022060878"]}],"id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["GM151274"],"award-info":[{"award-number":["GM151274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL173273"],"award-info":[{"award-number":["HL173273"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AG075834"],"award-info":[{"award-number":["AG075834"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AG080775"],"award-info":[{"award-number":["AG080775"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL144472"],"award-info":[{"award-number":["HL144472"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL152297"],"award-info":[{"award-number":["HL152297"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["UC2MD019626"],"award-info":[{"award-number":["UC2MD019626"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["CA293474"],"award-info":[{"award-number":["CA293474"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX00584"],"award-info":[{"award-number":["BX00584"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX002780"],"award-info":[{"award-number":["CX002780"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004722","name":"Stiftelsen Lars Hiertas Minne","doi-asserted-by":"publisher","award":["FO2023-0505"],"award-info":[{"award-number":["FO2023-0505"]}],"id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022885","name":"Oklahoma Center for Adult Stem Cell Research","doi-asserted-by":"publisher","award":["241009"],"award-info":[{"award-number":["241009"]}],"id":[{"id":"10.13039\/100022885","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["966924"],"award-info":[{"award-number":["966924"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25IVPHA1462290"],"award-info":[{"award-number":["25IVPHA1462290"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008444","name":"O. E. och Edla Johanssons Vetenskapliga Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008444","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009791","name":"Stiftelsen Apotekare Hedbergs Fond f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009791","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>Wound healing after myocardial infarction (MI) is a dynamic and multifaceted process that links the molecular alterations induced by or in response to prolonged ischemia with structural and physiological changes to the damaged myocardium. Changes, at the tissue level, are driven by a complex intersection of cellular and molecular mechanisms that operate along a classic wound healing paradigm as an attempt to repair the damaged myocardium and restore cardiac physiology. Maladaptive healing prevents a return to the original homeostasis, rather yielding a myocardium reset to a new homeostatic status that can lead to heart failure due to compromised contractility, increased chamber dilation, and cardiac fibrosis or due to sudden cardiac death resulting from arrhythmias. This review summarizes our current knowledge of how key inflammatory drivers in the myocardium (cardiomyocytes, neutrophils, monocytes\/macrophages, fibroblasts, and vascular endothelial cells) respond to molecular signals including cytokines, growth factors, and proteases to coordinate the wound healing process in the mouse model of MI. We also identify knowledge gaps that remain in our understanding of cardiac remodeling that are opportunities for future examinations.<\/jats:p>","DOI":"10.1152\/ajpheart.00891.2025","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:31:12Z","timestamp":1768408272000},"page":"H594-H609","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Cellular and molecular signals of cardiac wound healing after myocardial infarction"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-805X","authenticated-orcid":false,"given":"Hiroe","family":"Toba","sequence":"first","affiliation":[{"name":"Kyoto Pharmaceutical University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-9354","authenticated-orcid":false,"given":"Ganesh V.","family":"Halade","sequence":"additional","affiliation":[{"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9647-6112","authenticated-orcid":false,"given":"Kristine Y.","family":"DeLeon-Pennell","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina","place":["United States"]},{"name":"Ralph H. Johnson Veterans Affairs Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1256-4335","authenticated-orcid":false,"given":"Ying Ann","family":"Chiao","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation","place":["United States"]},{"name":"University of Oklahoma Health Sciences Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9648-7161","authenticated-orcid":false,"given":"Andriy","family":"Yabluchanskiy","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Campus","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Holm Nielsen","sequence":"additional","affiliation":[{"name":"Technical University of Denmark","place":["Denmark"]},{"name":"Nordic Bioscience","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-7697","authenticated-orcid":false,"given":"Upendra","family":"Chalise","sequence":"additional","affiliation":[{"name":"University of Minnesota, Twin Cities","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mediha","family":"Becirovic-Agic","sequence":"additional","affiliation":[{"name":"Uppsala University","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-8892","authenticated-orcid":false,"given":"Lisandra E.","family":"de Castro Braz","sequence":"additional","affiliation":[{"name":"East Carolina University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-0391","authenticated-orcid":false,"given":"Merry L.","family":"Lindsey","sequence":"additional","affiliation":[{"name":"Meharry Medical College","place":["United States"]},{"name":"Meharry Medical College","place":["United States"]},{"name":"Nashville VA Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90180-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1606915"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90159-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.07.005"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163111"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150006"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303577"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.25.2981"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00131.2018"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2828(05)82390-9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.301673"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060547"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/07853890310001285"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/biom11040491"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa287"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07493-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8815349"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1159\/000445882"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00335.2017"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00459.2021"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00234.2021"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00748.2024"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318241"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.11.009"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.04.011"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00068"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316306"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-10974-6"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07806-1"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw024"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy211"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.01.013"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2018.05.009"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00259.2019"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01153-w"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.073023"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.02.006"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13920"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065x.2000.917309.x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae089"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351449"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.01.062"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.323658"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12118"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199503000-00001"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.4.1474-1481.1993"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.1.377"},{"key":"B51","first-page":"393","volume":"144","author":"Ember JA","year":"1994","journal-title":"Am J Pathol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00360.2002"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.709871"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(84)80203-x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/s0753-3322(03)00065-9"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1584"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.02.001"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.12.018"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0746-x"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00679.2019"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1463-9"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.10.005"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.06.006"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071676"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00475.2021"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014442"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52812-6"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw085"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0686-x"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01105-4"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0363-8"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314028"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2017.10.001"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020857"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1039\/d1mo00519g"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.734229"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.17"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01840-1"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.07.017"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0715-4"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.07.008"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.03.001"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0809-6"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22322"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307778"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1242\/dev.079970"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12260"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2012.07.003"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.03.008"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.79.3.363"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119751"},{"key":"B92","first-page":"247","volume":"1","author":"Hernandez-Resendiz S","year":"2018","journal-title":"Cond Med"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.05.008"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0622-5"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/nri2779"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96800"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.115.001249"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.04.003"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10441-8"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00276.2023"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0444-7"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700109R"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-21735-8_6"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317200"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/nri3024"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2022.100485"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1588667"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.503"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70063"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0187OC"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801451"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.072411"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140685"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00230.2022"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000163017.13772.3a"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315069"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.216101"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000158"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4375127"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00457.2005"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109837"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2020.03.010"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00565.2024"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01070.2010"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00402.2014"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.02.006"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07524-x"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/87904"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.87"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302533"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315023"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.213"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2958"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1605fje"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.947531"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.203034"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf902"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.129"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1177\/1177271918771969"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-0965OC"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090121"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49511-4"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.05.010"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901444"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00614"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081244"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00040.2016"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98215"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.162891"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.12.025"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.209809"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs259"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09045"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2015.1022526"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4MR0316-102R"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.02.010"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-018-0060-4"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.127"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1172\/JCI99659"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs487"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035905"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63598-5"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00224.2013"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1113\/JP283346"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309001"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.04.007"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.05.013"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20361-3"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-021-00352-w"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00112.2019"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2020.04.001"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00250.2023"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.044164"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00082.2021"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314370"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82210-4"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198904000-00015"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-020-01775-9"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.08.010"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206965"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.02.007"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006155"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn268"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.07.018"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00172.2018"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.912572"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20905-1"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030742"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57613-8_11"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109828"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322556"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041170"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00028.2019"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00642.2019"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001309"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.12.024"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111944"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00267.2025"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.020"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00833.2024"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b02207"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.09.023"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1113\/EP090888"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00612.2021"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.08.014"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv034"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00453.2017"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1038\/npjamd.2016.18"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2025.07.003"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-020-00793-2"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2019.1664293"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0699-5"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94207"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005491"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.15341"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00891.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:22:10Z","timestamp":1770304930000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00891.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":215,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/ajpheart.00891.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00891.2025","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}